Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults.
Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults.
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来自印度儿童、青少年和年轻人的多中心队列的风险聚类和精神病理学。
DOI：
10.1017/s0954579422000050
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发表时间：
2023
影响因子：
3.3
通讯作者：
Basu D
中科院分区：
文献类型：
--
作者：
Basu D
生命早期的发展逆境与后来的精神病理学有关。聚类可能是一种有用的方法，将多种不同的风险集中在一起，并研究它们与精神病理学的关系。根据不良环境暴露和发育特征，生成儿童、青少年和年轻人的风险群，并检查风险群与明显精神病理学的关联。参与者（n = 8300）之间的6和23岁，从7个地点在印度招募。我们进行问卷调查，以了解儿童期不良环境的既往暴露史、一级亲属的精神疾病家族史以及一系列产前和产后逆境。我们使用这些变量来生成风险聚类。进行Mini-International Neuropsychiatric Interview-5以评估明显的精神病理学。两步聚类分析显示两个集群指定为高风险集群（HRC）和低风险集群（LRC），分别包括4197（50.5%）和4103（49.5%）的参与者。HRC有更高的频率的精神疾病家族史，产前和新生儿的危险因素，发育迟缓，移民史，暴露于不良的童年经历比LRC。HRC中任何精神疾病[相对风险（RR）= 2.0，95% CI 1.8-2.3]、外化（RR = 4.8，95% CI 3.6-6.4）和内化疾病（RR = 2.6，95% CI 2.2-2.9）以及自杀倾向（2.3，95% CI 1.8-2.8）的风险显著较高。社会环境和发展因素可以将印度儿童，青少年和年轻人分为同质集群，精神病理学风险高或低。这些心理健康的生物心理社会决定因素可能对低收入和中等收入国家的人们产生实践、政策和研究影响。
Developmental adversities early in life are associated with later psychopathology. Clustering may be a useful approach to group multiple diverse risks together and study their relation with psychopathology. To generate risk clusters of children, adolescents, and young adults, based on adverse environmental exposure and developmental characteristics, and to examine the association of risk clusters with manifest psychopathology. Participants (n = 8300) between 6 and 23 years were recruited from seven sites in India. We administered questionnaires to elicit history of previous exposure to adverse childhood environments, family history of psychiatric disorders in first-degree relatives, and a range of antenatal and postnatal adversities. We used these variables to generate risk clusters. Mini-International Neuropsychiatric Interview-5 was administered to evaluate manifest psychopathology. Two-step cluster analysis revealed two clusters designated as high-risk cluster (HRC) and low-risk cluster (LRC), comprising 4197 (50.5%) and 4103 (49.5%) participants, respectively. HRC had higher frequencies of family history of mental illness, antenatal and neonatal risk factors, developmental delays, history of migration, and exposure to adverse childhood experiences than LRC. There were significantly higher risks of any psychiatric disorder [Relative Risk (RR) = 2.0, 95% CI 1.8–2.3], externalizing (RR = 4.8, 95% CI 3.6–6.4) and internalizing disorders (RR = 2.6, 95% CI 2.2–2.9), and suicidality (2.3, 95% CI 1.8–2.8) in HRC. Social-environmental and developmental factors could classify Indian children, adolescents and young adults into homogeneous clusters at high or low risk of psychopathology. These biopsychosocial determinants of mental health may have practice, policy and research implications for people in low- and middle-income countries.
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影响因子：
--
作者：
Green, Jennifer Greif;McLaughlin, Katie A.;Berglund, Patricia A.;Gruber, Michael J.;Sampson, Nancy A.;Zaslavsky, Alan M.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
影响因子：
4.7
作者：
Uher R
通讯作者：
Uher R
多名成员被诊断患有精神疾病的家庭的不良童年经历
DOI：
--
发表时间：
2019
期刊：
bioRxiv
影响因子：
--
作者：
Amala Someshwar;Amala Someshwar;B. Holla;P. Agarwal;A. Thomas;Anand Jose;Boban Joseph;Birudu Raju;H. Karle;M. Muthukumaran;P. Kodancha;Pramod Kumar;P. Reddy;R. Nadella;Sanjay T Naik;S. Mitra;Sreenivasulu Mallappagiri;V. S. Sreeraj;S. Balachander;S. Ganesh;P. Murthy;V. Benegal;Janardhan Y. C. Reddy;S. Jain;J. Mahadevan;B. Viswanath
通讯作者：
B. Viswanath
DOI：
10.1176/ajp.150.3.511
发表时间：
1993
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Fristad,MA;Jedel,R;Weller,RA;Weller,EB
通讯作者：
Weller,EB
青少年吸毒模式的顺序和阶段。
影响因子：
--
作者：
D. Kandel;R. Faust
通讯作者：
R. Faust