Marine Microalgae with Anti-Cancer Properties.
Marine Microalgae with Anti-Cancer Properties.
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DOI：
10.3390/md16050165
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发表时间：
2018-05-15
期刊：
影响因子：
5.4
通讯作者：
Ianora A
中科院分区：
文献类型：
--
作者：
Martínez Andrade KA;Lauritano C;Romano G;Ianora A
癌症是全球死亡的主要原因，寻找新的癌症治疗药物仍然是寻求治愈的主要挑战。本文对具有抗癌活性的微藻进行了综述。微藻是真核单细胞植物，占全球初级生产力的40%。它们是色素、脂质、类胡萝卜素、ω-3脂肪酸、多糖、维生素和其他精细化学品的极好来源，并且对它们用作营养品和食品补充剂的需求日益增加。据报道，一些微藻也具有抗癌活性。在这篇综述中，我们报道了具有抗癌特性的微藻物种，受藻类影响的癌细胞系以及测试诱导细胞生长停滞的化合物/提取物的浓度。我们还报告了用于生长具有抗癌活性的微藻的培养基，并将这些微藻的生物活性与已经上市的海洋抗癌药物和III期临床试验进行了比较。最后，我们讨论了为什么一些微藻可以成为未来开发的抗癌化合物的有前途的来源。
Cancer is the leading cause of death globally and finding new therapeutic agents for cancer treatment remains a major challenge in the pursuit for a cure. This paper presents an overview on microalgae with anti-cancer activities. Microalgae are eukaryotic unicellular plants that contribute up to 40% of global primary productivity. They are excellent sources of pigments, lipids, carotenoids, omega-3 fatty acids, polysaccharides, vitamins and other fine chemicals, and there is an increasing demand for their use as nutraceuticals and food supplements. Some microalgae are also reported as having anti-cancer activity. In this review, we report the microalgal species that have shown anti-cancer properties, the cancer cell lines affected by algae and the concentrations of compounds/extracts tested to induce arrest of cell growth. We also report the mediums used for growing microalgae that showed anti-cancer activity and compare the bioactivity of these microalgae with marine anticancer drugs already on the market and in phase III clinical trials. Finally, we discuss why some microalgae can be promising sources of anti-cancer compounds for future development.
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影响因子：
5.4
作者：
Luo X;Su P;Zhang W
通讯作者：
Zhang W
影响因子：
--
作者：
de Morais MG;Vaz Bda S;de Morais EG;Costa JA
通讯作者：
Costa JA
影响因子：
4.2
作者：
Kotake-Nara, E;Kushiro, M;Nagao, A
通讯作者：
Nagao, A
影响因子：
5.1
作者：
Andrianasolo, Eric H.;Haramaty, Liti;Falkowski, Paul
通讯作者：
Falkowski, Paul
影响因子：
20.3
作者：
Francisco, JA;Cerveny, CG;Wahl, AF
通讯作者：
Wahl, AF