Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer.
Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer.
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用姜黄素作为自然风光的光敏剂的最新创新和纳米技术应用于癌症的光动力疗法。
DOI：
10.3390/pharmaceutics13101562
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发表时间：
2021-09-26
期刊：
影响因子：
5.4
通讯作者：
Litscher G
中科院分区：
文献类型：
--
作者：
Ailioaie LM;Ailioaie C;Litscher G
在全球癌症高发的背景下，最先进的光动力疗法（PDT）已成为尝试根除癌症的微创手术的常用方案，以及药物资源和放射疗法。光敏剂（PS）在特定波长的光源下激发，在氧气存在的情况下释放出多种自由基和各种具有高细胞毒性潜力的氧化产物，这将导致受照射的癌组织中的细胞死亡。目前的研究重点是天然产物作为新一代光敏剂的潜力，它通过最新的纳米技术更好地靶向肿瘤，对邻近组织的毒性较小，但同时改善了更具侵袭性和广泛性的癌症的光吸收。融入纳米技术的姜黄素具有更高的细胞内吸收、更高的靶向率、增加对肿瘤细胞的毒性、加速caspases的活性和DNA裂解、降低癌细胞的线粒体活性、降低其活力和增殖、减少血管生成，最终诱导细胞凋亡。它可以缩小原发肿瘤的大小，逆转化疗的多药耐药性，并降低肿瘤对放射治疗的耐药性。目前的研究表明，PDT和姜黄素纳米制剂的使用对ROS的产生具有调节作用，因此光或激光照射会导致ROS过度生长，而纳米姜黄素会减少ROS产生酶的活化或决定ROS的快速去除，看似相反但通过诱导肿瘤细胞凋亡而产生协同作用，但同时加速附近组织的修复。最新的姜黄素纳米制剂在优化 PDT、克服主要副作用、化疗耐药、复发和转移方面具有巨大潜力。所有回顾和提出的研究都揭示了姜黄素纳米制剂和 PDT 在癌症治疗中的巨大应用潜力。
In the context of the high incidence of cancer worldwide, state-of-the-art photodynamic therapy (PDT) has entered as a usual protocol of attempting to eradicate cancer as a minimally invasive procedure, along with pharmacological resources and radiation therapy. The photosensitizer (PS) excited at certain wavelengths of the applied light source, in the presence of oxygen releases several free radicals and various oxidation products with high cytotoxic potential, which will lead to cell death in irradiated cancerous tissues. Current research focuses on the potential of natural products as a superior generation of photosensitizers, which through the latest nanotechnologies target tumors better, are less toxic to neighboring tissues, but at the same time, have improved light absorption for the more aggressive and widespread forms of cancer. Curcumin incorporated into nanotechnologies has a higher intracellular absorption, a higher targeting rate, increased toxicity to tumor cells, accelerates the activity of caspases and DNA cleavage, decreases the mitochondrial activity of cancer cells, decreases their viability and proliferation, decreases angiogenesis, and finally induces apoptosis. It reduces the size of the primary tumor, reverses multidrug resistance in chemotherapy and decreases resistance to radiation therapy in neoplasms. Current research has shown that the use of PDT and nanoformulations of curcumin has a modulating effect on ROS generation, so light or laser irradiation will lead to excessive ROS growth, while nanocurcumin will reduce the activation of ROS-producing enzymes or will determine the quick removal of ROS, seemingly opposite but synergistic phenomena by inducing neoplasm apoptosis, but at the same time, accelerating the repair of nearby tissue. The latest curcumin nanoformulations have a huge potential to optimize PDT, to overcome major side effects, resistance to chemotherapy, relapses and metastases. All the studies reviewed and presented revealed great potential for the applicability of nanoformulations of curcumin and PDT in cancer therapy.
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DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
DOI：
10.1080/21691401.2020.1725023
发表时间：
2020-01-01
影响因子：
5.8
作者：
do Bonfim, Caroline Measso;Monteleoni, Leticia Figueiredo;Rahal, Paula
通讯作者：
Rahal, Paula
影响因子：
2.4
作者：
Bander, Thomas S.;Nehal, Kishwer S.;Lee, Erica H.
通讯作者：
Lee, Erica H.
影响因子：
34.3
作者：
Arbyn, Marc;Weiderpass, Elisabete;Bray, Freddie
通讯作者：
Bray, Freddie
影响因子：
5.2
作者：
Ambreen G;Duse L;Tariq I;Ali U;Ali S;Pinnapireddy SR;Bette M;Bakowsky U;Mandic R
通讯作者：
Mandic R