Role of macrophages in the pathogenesis of atopic dermatitis.
Role of macrophages in the pathogenesis of atopic dermatitis.
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DOI：
10.1155/2013/942375
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发表时间：
2013
影响因子：
4.6
通讯作者：
Werfel T
中科院分区：
文献类型：
--
作者：
Kasraie S;Werfel T
特应性皮炎(AD)是最常见、研究最深入的慢性炎症性皮肤病之一。一些辅助因素，如皮肤屏障功能受损，免疫系统的改变，以及复杂的遗传背景，指导着AD的进程。在这个复杂的网络中，巨噬细胞在增强对皮肤感染的易感性方面发挥着关键作用，并在细胞水平上充当AD发病机制的中心连接组件。在AD中，已知巨噬细胞在急性和慢性炎症的皮肤中积聚。在炎症的早期和短期，巨噬细胞发挥促炎功能，如抗原递呈吞噬和产生炎性细胞因子和生长因子，以促进炎症的消退。然而，促炎活性的持续存在和巨噬细胞功能的改变导致了慢性炎症性疾病的发展，如AD。巨噬细胞在这些过程中激活的确切机制尚不完全清楚。在AD中巨噬细胞激活的失调机制有待进一步研究，这将使我们能够针对这些具有多种功能的细胞进行治疗，从而改善和控制疾病。在这篇文章中，我们重点介绍了巨噬细胞功能失调的新发现，以及这些细胞在AD发病机制中的重要性，特别是这些细胞在增强对微生物感染的易感性方面的贡献。
Atopic dermatitis (AD) is one of the most common and most intensively studied chronic inflammatory skin diseases. Several cofactors, such as an impaired skin barrier function, modifications of the immune system, and a complex genetic background, direct the course of AD. Within this complex network, macrophages play a pivotal role in enhanced susceptibility to cutaneous infections and act as central connecting components in the pathogenesis of AD on the cellular level. In AD, macrophages are known to accumulate in acutely and chronically inflamed skin. During the early and short inflammatory phase, macrophages exert proinflammatory functions like antigen-presenting phagocytosis and the production of inflammatory cytokines and growth factors that facilitate the resolution of inflammation. However, persistence of pro-inflammatory activity and altered function of macrophages result in the development of chronic inflammatory diseases such as AD. The exact mechanism of macrophages activation in these processes is not yet completely understood. Further studies should be performed to clarify the dysregulated mechanism of macrophages activation in AD, and this would allow us to target these cells with versatile functions for therapeutic purpose and improve and control the disease. In this paper, we highlight the new findings on dysregulated function of macrophages and the importance of these cells in the pathogenesis of AD in general and the contribution of these cells in enhanced susceptibility against microbial infections in particular.
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DOI：
10.4049/jimmunol.1100500
发表时间：
2011-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ather JL;Ckless K;Martin R;Foley KL;Suratt BT;Boyson JE;Fitzgerald KA;Flavell RA;Eisenbarth SC;Poynter ME
通讯作者：
Poynter ME
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
4.8
作者：
Girardin, SE;Travassos, LH;Mengin-Lecreulx, D
通讯作者：
Mengin-Lecreulx, D
影响因子：
14.2
作者：
Guttman-Yassky, Emma;Nograles, Kristine E.;Krueger, James G.
通讯作者：
Krueger, James G.
影响因子：
3.1
作者：
Deshmukh, Hitesh S.;Hamburger, James B.;Fowler, Vance G., Jr.
通讯作者：
Fowler, Vance G., Jr.