Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs.
Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs.
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DOI：
10.1038/s41598-021-82945-3
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发表时间：
2021-02-09
影响因子：
4.6
通讯作者：
O'Malley BW
中科院分区：
文献类型：
--
作者：
Nikolai BC;Jain P;Cardenas DL;York B;Feng Q;McKenna NJ;Dasgupta S;Lonard DM;O'Malley BW
调节性T细胞(Tregs)是CD4TERG淋巴细胞的一个亚群，是中枢耐受所必需的，其功能是抑制自身抗原的自身免疫。SRC-3共激活因子是多种癌症中的癌基因，能够在多种细胞类型中增强多种转录因子。SRC-3基因敲除小鼠表现出广泛的淋巴增殖和对全身炎症的超敏。利用公开的生物信息学数据和定向细胞方法，我们表明SRC-3在小鼠和人类中也高度富含Treg。当SRC-3被耗尽或被药物抑制时，人类Tregs会失去表型特征，包括无法从静止的T细胞诱导，失去抑制刺激的T细胞增殖的能力。这些数据支持SRC-3作为共激活因子的模型，该模型积极参与对自身免疫的保护，并可能通过对Treg生物学的贡献来支持癌症的免疫逃逸。
A subset of CD4 + lymphocytes, regulatory T cells (Tregs), are necessary for central tolerance and function as suppressors of autoimmunity against self-antigens. The SRC-3 coactivator is an oncogene in multiple cancers and is capable of potentiating numerous transcription factors in a wide variety of cell types. Src-3 knockout mice display broad lymphoproliferation and hypersensitivity to systemic inflammation. Using publicly available bioinformatics data and directed cellular approaches, we show that SRC-3 also is highly enriched in Tregs in mice and humans. Human Tregs lose phenotypic characteristics when SRC-3 is depleted or pharmacologically inhibited, including failure of induction from resting T cells and loss of the ability to suppress proliferation of stimulated T cells. These data support a model for SRC-3 as a coactivator that actively participates in protection from autoimmunity and may support immune evasion of cancers by contributing to the biology of Tregs.
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影响因子：
10.5
作者：
Dasgupta S;Lonard DM;O'Malley BW
通讯作者：
O'Malley BW
影响因子：
5.1
作者：
Van Tendeloo, VFI;Willems, R;Berneman, ZN
通讯作者：
Berneman, ZN
DOI：
10.1084/jem.20130762
发表时间：
2013-10-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bos PD;Plitas G;Rudra D;Lee SY;Rudensky AY
通讯作者：
Rudensky AY
影响因子：
16.6
作者：
Hwang SS;Jang SW;Kim MK;Kim LK;Kim BS;Kim HS;Kim K;Lee W;Flavell RA;Lee GR
通讯作者：
Lee GR
影响因子：
11.4
作者：
Coste, Agnes;Antal, Maria Cristina;Auwerx, Johan
通讯作者：
Auwerx, Johan