The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics.
The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics.
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DOI：
10.1590/1516-4446-2021-1926
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Kloiber S
中科院分区：
文献类型：
--
作者：
Ahmed M;Boileau I;Le Foll B;Carvalho AF;Kloiber S
社交焦虑障碍（SAD）是一种高度流行的精神疾病，表现为发病年龄早，病程慢性，精神并发症的风险增加。目前SAD的治疗选择与低应答率、次优疗效和可能的不良反应风险相关。新的神经生物学机制的调查可能有助于确定更具体的治疗靶点治疗这种疾病。新出现的证据表明，内源性大麻素系统，也被称为内源性大麻素系统（ECS），可能在SAD的病理生理学中发挥潜在的作用。这篇综述讨论了已知的SAD的病理生理机制，ECS在这种疾病中的潜在作用，目前靶向ECS的药物，以及这些新化合物的潜力，以提高SAD的治疗armamentarium。进一步的研究工作，特别是在人群中，有必要提高我们对SAD中ECS的认识。
Social anxiety disorder (SAD) is a highly prevalent psychiatric disorder that presents with an early age of onset, chronic disease course, and increased risk of psychiatric comorbidity. Current treatment options for SAD are associated with low response rates, suboptimal efficacy, and possible risk of adverse effects. Investigation of new neurobiological mechanisms may aid in the identification of more specific therapeutic targets for the treatment of this disorder. Emerging evidence suggests that the endogenous cannabinoid system, also referred to as the endocannabinoid system (ECS), could play a potential role in the pathophysiology of SAD. This review discusses the known pathophysiological mechanisms of SAD, the potential role of the ECS in this disorder, current drugs targeting the ECS, and the potential of these novel compounds to enhance the therapeutic armamentarium for SAD. Further investigational efforts, specifically in human populations, are warranted to improve our knowledge of the ECS in SAD.
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影响因子：
6.8
作者：
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通讯作者：
Patel S
DOI：
10.1016/j.pnpbp.2012.10.024
发表时间：
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作者：
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