Chalcone: A Privileged Structure in Medicinal Chemistry.
Chalcone: A Privileged Structure in Medicinal Chemistry.
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查尔酮：药物化学中的一种特殊结构。
DOI：
10.1021/acs.chemrev.7b00020
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发表时间：
2017-06-28
期刊：
影响因子：
62.1
通讯作者：
Miao Z
中科院分区：
文献类型：
--
作者：
Zhuang C;Zhang W;Sheng C;Zhang W;Xing C;Miao Z
特权结构作为药物化学中药物发现的有效模板得到了广泛的应用。查尔酮是一种常见的简单支架，存在于许多天然化合物中。由于合成方便，许多查尔酮衍生物也已被制备出来。这些天然产物和合成化合物显示出许多有趣的生物活性，具有治疗各种疾病的临床潜力。这篇综述旨在强调查尔酮作为药物化学中一种特权支架的最新证据。本文将对查尔酮的多个方面进行综述，包括新的查尔酮衍生物的分离、新合成方法的开发、其生物学性质的评价、作用机制的探索以及靶标识别。这项审查预计将是对化学界查尔酮模板的全面、权威和批判性审查。
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.
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