Newborn jaundice technologies: unbound bilirubin and bilirubin binding capacity in neonates.
Newborn jaundice technologies: unbound bilirubin and bilirubin binding capacity in neonates.
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DOI：
10.1053/j.semperi.2011.02.007
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发表时间：
2011-06
影响因子：
3.4
通讯作者：
Lamola AA
中科院分区：
文献类型：
--
作者：
Amin SB;Lamola AA
新生儿黄疸（高胆红素血症）在新生儿中极为常见，可能与神经毒性有关。未确定早产儿或足月儿胆红素的安全水平。新出现的证据表明，对于胆红素诱导的神经毒性，未结合（或“游离”）胆红素水平比血清总胆红素具有更好的灵敏度和特异性。虽然最近的研究表明游离胆红素测量在管理高危新生儿（包括早产儿）中的有用性，但目前还没有广泛可用的方法来测定血清游离胆红素浓度。为了跟上不断增长的需求，除了重新评估旧方法外，正在开发几种有前途的新方法，用于灵敏，准确和快速测量游离胆红素和胆红素结合能力。这些创新的方法需要在临床应用之前进行验证。我们提供了一些有前途的游离胆红素和结合能力的测量方法的概述，目的是加强在这一领域的积极兴趣和明显的需要的研究。
Neonatal jaundice (hyperbilirubinemia), extremely common in neonates, can be associated with neurotoxicity. A safe level of bilirubin has not been defined in either premature or term infants. Emerging evidence suggest that the level of unbound (or “free”) bilirubin has a better sensitivity and specificity than total serum bilirubin for bilirubin-induced neurotoxicity. Although recent studies suggest the usefulness of free bilirubin measurements in managing high-risk neonates including premature infants, there currently exists no widely available method to assay the serum free bilirubin concentration. To keep pace with the growing demand, in addition to reevaluation of old methods, several promising new methods are being developed for sensitive, accurate, and rapid measurement of free bilirubin and bilirubin binding capacity. These innovative methods need to be validated before adopting for clinical use. We provide an overview of some promising methods for free bilirubin and binding capacity measurements with the goal to enhance research in this area of active interest and apparent need.
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影响因子：
6.1
作者：
Andreu, Y;Ostra, M;Castillo, JR
通讯作者：
Castillo, JR
影响因子：
5.2
作者：
BRATLID, D
通讯作者：
BRATLID, D
影响因子：
3.4
作者：
Hansen, Thor Willy Ruud
通讯作者：
Hansen, Thor Willy Ruud
影响因子：
3.6
作者：
Calligaris, Sebastian D.;Bellarosa, Cristina;Tiribelli, Claudio
通讯作者：
Tiribelli, Claudio
影响因子：
5
作者：
Ahlfors, CE;Marshall, GD;Van Overmeire, B
通讯作者：
Van Overmeire, B