Epidemiologic features and prognostic factors of coronary artery lesions associated with Kawasaki disease based on a 13-year cohort of consecutive cases identified by complete enumeration surveys in Wakayama, Japan.
Epidemiologic features and prognostic factors of coronary artery lesions associated with Kawasaki disease based on a 13-year cohort of consecutive cases identified by complete enumeration surveys in Wakayama, Japan.
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DOI：
10.2188/jea.je20140018
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发表时间：
2014
影响因子：
4.7
通讯作者：
Wakayama Kawasaki Disease Study Group
中科院分区：
文献类型：
--
作者：
Kitano N;Suzuki H;Takeuchi T;Suenaga T;Kakimoto N;Shibuta S;Yoshikawa N;Takeshita T;Wakayama Kawasaki Disease Study Group
为了阐明患者年龄在川崎病(KD)相关冠状动脉病变(CAL)发生中的作用，在特定地区采用医院全面清点调查的方法对其流行病学特征和预后因素进行了调查。对日本和歌山县1999年10月至2012年9月期间发现的连续KD病例进行了分析。主要观察指标为发病1个月后超声心动图上有无CALS(巨大、中、小型动脉瘤和扩张)。比较有无CALS患者的人口学特征和内科治疗因素。确定CALS发生的解释变量(年龄、性别和大剂量静脉注射免疫球蛋白治疗相关因素)的优势比(OR)和95%可信区间(CI)。1415名患者(男性796名，女性619名)在排除2名外国居民子女后的中位年龄为25个月；2.2%的患者既往有KD病史，1.8%的患者表现不完全。CALS的发生率为3.3%(男性4.0%，女性2.3%；P=0.080)。11个月龄组(3.0，95%CI 1.4~6.6)和48个月龄组(3.1，95%CI 1.5~6.6)CALS的OR值显著高于11~48个月龄组。患者年龄对CALS的影响呈U型，11~48个月年龄最低。这一发现是基于对特定地区连续13年的KD病例进行的队列调查，几乎没有选择偏倚，与先前报道的结果一致。
To clarify the contribution of patient age to the development of coronary artery lesions (CALs) associated with Kawasaki disease (KD), epidemiologic features and prognostic factors were investigated using hospital-based complete enumeration surveys in a specific area. Consecutive KD cases identified between October 1999 and September 2012 in Wakayama Prefecture, Japan, were analyzed. The primary outcome measure was the presence/absence of CALs (giant aneurysm, mid- or small-sized aneurysm, and dilatation) on echocardiography 1 month after disease onset. Demographics and medical treatment factors were compared between the patients with and without CALs. Odds ratios (ORs) and 95% confidence intervals (CIs) of explanatory variables (age, gender, and factors related to high-dose intravenous immunoglobulin treatment) for the development of CALs were determined. The median age of the 1415 patients (796 males, 619 females) was 25 months after excluding 2 children of foreign residents; 2.2% of the patients had a past history of KD, and 1.8% showed incomplete presentation. CALs were observed in 3.3% (4.0% of males, 2.3% of females; P = 0.080). The ORs of CALs among patients <11 months old (3.0, 95% CI 1.4–6.6) and those >48 months old (3.1, 95% CI 1.5–6.6) were significantly higher than values in 11- to 48-month-olds. The effect of patient age on the development of CALs was found to be U-shaped, with the bottom at ages 11 to 48 months. This finding was based on a 13-year cohort of consecutive KD cases in a specific area with little selection bias and is consistent with previously reported results.
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DOI：
10.1097/inf.0b013e31817acf4f
发表时间：
2008-11
期刊：
The Pediatric infectious disease journal
影响因子：
--
作者：
Kao AS;Getis A;Brodine S;Burns JC
通讯作者：
Burns JC
影响因子：
3.6
作者：
Belay, ED;Maddox, RA;Schonberger, LB
通讯作者：
Schonberger, LB
影响因子：
3.6
作者：
Holman, Robert C.;Belay, Ermias D.;Schonberger, Lawrence B.
通讯作者：
Schonberger, Lawrence B.
影响因子：
8
作者：
Manlhiot, Cedric;Yeung, Rae S. M.;McCrindle, Brian W.
通讯作者：
McCrindle, Brian W.
影响因子：
4.7
作者：
Nakamura, Yosikazu;Yashiro, Mayumi;Yanagawa, Hiroshi
通讯作者：
Yanagawa, Hiroshi