Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology.
Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology.
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DOI：
10.1016/j.pharmthera.2011.01.008
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发表时间：
2011-04
影响因子：
13.5
通讯作者：
Sarkar, Devanand
中科院分区：
文献类型：
--
作者：
Yoo, Byoung Kwon;Emdad, Luni;Lee, Seok-Geun;Su, Zao-zhong;Santhekadur, Prasanna;Chen, Dong;Gredler, Rachel;Fisher, Paul B.;Sarkar, Devanand
关键词：
自2002年首次鉴定和克隆以来，星形胶质细胞升高基因-1（AEG-1），也称为metadherin（MTDH），3D 3和赖氨酸-RIch CEACAM 1共分离（LYRIC），已成为一种重要的癌基因，在迄今为止分析的所有癌症中过表达。对代表不同癌症适应症的大量患者样本的检查显示，AEG-1表达随着疾病的分期和分级而进行性增加，AEG-1表达水平与患者预后呈负相关。AEG-1作为一个真正的癌基因通过促进转化发挥作用。此外，它在侵袭、转移、血管生成和化疗耐药性中发挥重要作用，这些都是侵袭性癌症的重要标志。AEG-1还涉及多种生理和病理过程，如发育、炎症、神经变性、偏头痛和亨廷顿病。AEG-1是一种具有跨膜结构域和多个核定位信号的碱性蛋白，存在于细胞膜、细胞质、细胞核、核仁和内质网中。在每个位置，AEG-1与特定的蛋白质相互作用，从而调节不同的细胞内过程，这些过程的组合有助于其多效性。本综述提供了一个快照，目前的文献沿着与未来的观点，这种独特的分子。
Since its initial identification and cloning in 2002, Astrocyte Elevated Gene-1 (AEG-1), also known as metadherin (MTDH), 3D3 and LYsine-RIch CEACAM1 co-isolated (LYRIC), has emerged as an important oncogene that is overexpressed in all cancers analyzed so far. Examination of a large cohort of patient samples representing diverse cancer indications has revealed progressive increase in AEG-1 expression with stages and grades of the disease and an inverse relationship between AEG-1 expression level and patient prognosis. AEG-1 functions as a bona fide oncogene by promoting transformation. In addition, it plays a significant role in invasion, metastasis, angiogenesis and chemoresistance, all important hallmarks of an aggressive cancer. AEG-1 is also implicated in diverse physiological and pathological processes, such as development, inflammation, neurodegeneration, migraine and Huntington disease. AEG-1 is a highly basic protein with a transmembrane domain and multiple nuclear localization signals and it is present in the cell membrane, cytoplasm, nucleus, nucleolus and endoplasmic reticulum. In each location, AEG-1 interacts with specific proteins thereby modulating diverse intracellular processes the combination of which contributes to its pleiotrophic properties. The present review provides a snapshot of the current literature along with future perspectives on this unique molecule.
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影响因子：
50.3
作者：
Hu G;Chong RA;Yang Q;Wei Y;Blanco MA;Li F;Reiss M;Au JL;Haffty BG;Kang Y
通讯作者：
Kang Y
影响因子：
1.2
作者：
Jeon, Hyun Yong;Choi, Murim;Fisher, Paul B.
通讯作者：
Fisher, Paul B.
DOI：
10.1073/pnas.0910936106
发表时间：
2009-12-15
影响因子：
11.1
作者：
Emdad, Luni;Lee, Seok-Geun;Fisher, Paul B.
通讯作者：
Fisher, Paul B.
影响因子：
4.8
作者：
Carnemolla, Alisia;Fossale, Elisa;Persichetti, Francesca
通讯作者：
Persichetti, Francesca
肾细胞癌中 AEG-1 的过度表达及其与肿瘤核分级和进展的相关性。
影响因子：
3
作者：
Chen, W.;Ke, Z.;Wang, L.
通讯作者：
Wang, L.