Exploiting Anopheles responses to thermal, odour and visual stimuli to improve surveillance and control of malaria.
Exploiting Anopheles responses to thermal, odour and visual stimuli to improve surveillance and control of malaria.
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DOI：
10.1038/s41598-017-17632-3
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发表时间：
2017-12-11
影响因子：
4.6
通讯作者：
Gibson G
中科院分区：
文献类型：
--
作者：
Hawkes FM;Dabiré RK;Sawadogo SP;Torr SJ;Gibson G
蚊子监测和控制是消除疟疾努力的核心，然而，我们对阻碍创新的蚊子行为的理解仍然存在重大差距。我们假设，人类相关刺激的组合可以用来吸引和杀死疟疾媒介，比单独的刺激更成功，至少和真人一样。为了在实地测试这一点，我们在布基纳法索使用简单的粘性陷阱量化了按蚊对嗅觉、视觉和热刺激的反应。带有人类气味和高对比度视觉刺激的陷阱比单独使用气味的陷阱捕捉到的按蚊更多，这表明尽管疟疾媒介有夜间习性，但它们利用视觉线索寻找宿主。然而，性能最好的陷阱将气味和视觉刺激与热特征结合在一起，范围相当于人体温度。在蚊子数量达到高峰时，这种“宿主诱饵”诱捕器捕捉到的按蚊数量几乎是人类收集者捕获的数量的十倍。利用蚊子对整个宿主刺激的行为反应有望使媒介监测发生革命性变化，并为疾病控制提供新的范例。
Mosquito surveillance and control are at the heart of efforts to eliminate malaria, however, there remain significant gaps in our understanding of mosquito behaviour that impede innovation. We hypothesised that a combination of human-associated stimuli could be used to attract and kill malaria vectors more successfully than individual stimuli, and at least as well as a real human. To test this in the field, we quantified Anopheles responses to olfactory, visual and thermal stimuli in Burkina Faso using a simple adhesive trap. Traps baited with human odour plus high contrast visual stimuli caught more Anopheles than traps with odour alone, showing that despite their nocturnal habit, malaria vectors make use of visual cues in host-seeking. The best performing traps, however, combined odour and visual stimuli with a thermal signature in the range equivalent to human body temperature. When tested against a human landing catch during peak mosquito abundance, this “host decoy” trap caught nearly ten times the number of Anopheles mosquitoes caught by a human collector. Exploiting the behavioural responses of mosquitoes to the entire suite of host stimuli promises to revolutionise vector surveillance and provide new paradigms in disease control.
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影响因子：
8.1
作者：
Killeen GF;Marshall JM;Kiware SS;South AB;Tusting LS;Chaki PP;Govella NJ
通讯作者：
Govella NJ
影响因子：
3.2
作者：
Kenea O;Balkew M;Tekie H;Gebre-Michael T;Deressa W;Loha E;Lindtjørn B;Overgaard HJ
通讯作者：
Overgaard HJ
影响因子：
3.3
作者：
James, Stephanie;Takken, Willem;Gottlieb, Michael
通讯作者：
Gottlieb, Michael
影响因子：
9.8
作者：
Hemingway J;Shretta R;Wells TN;Bell D;Djimdé AA;Achee N;Qi G
通讯作者：
Qi G
影响因子：
3
作者：
Mathenge EM;Misiani GO;Oulo DO;Irungu LW;Ndegwa PN;Smith TA;Killeen GF;Knols BG
通讯作者：
Knols BG