Ceramide and Related Molecules in Viral Infections.
Ceramide and Related Molecules in Viral Infections.
复制标题
病毒感染中的神经酰胺和相关分子。
DOI：
10.3390/ijms22115676
复制
发表时间：
2021-05-26
影响因子：
5.6
通讯作者：
Becker KA
中科院分区：
文献类型：
--
作者：
Beckmann N;Becker KA
神经酰胺是鞘脂代谢核心的脂质信使。与其代谢酶，特别是鞘磷脂酶，它在调节生物膜的物理性质，包括膜微区的形成中起关键作用。因此，神经酰胺及其相关分子在病毒生命周期的几乎所有步骤中都具有重要作用：它们可以直接作为病毒进入的受体或共受体，形成聚集进入受体的微结构域和/或使它们能够采用所需的构象或调节它们的细胞表面表达。鞘脂可以调节所有形式的病毒摄取，通常通过鞘磷脂酶激活，并介导内体逃逸和细胞内运输。神经酰胺可能是病毒复制位点形成的关键。鞘磷脂酶通常介导新病毒体从感染细胞中释放。此外，鞘脂可导致病毒诱导的细胞凋亡和病毒性疾病的发病率，以及病毒免疫逃避。特别地，α-半乳糖神经酰胺还在响应病毒感染的免疫调节中起重要作用。本文将讨论神经酰胺及其相关分子在病毒生命周期不同阶段的作用。我们还将讨论新的策略如何利用这些治疗益处。
Ceramide is a lipid messenger at the heart of sphingolipid metabolism. In concert with its metabolizing enzymes, particularly sphingomyelinases, it has key roles in regulating the physical properties of biological membranes, including the formation of membrane microdomains. Thus, ceramide and its related molecules have been attributed significant roles in nearly all steps of the viral life cycle: they may serve directly as receptors or co-receptors for viral entry, form microdomains that cluster entry receptors and/or enable them to adopt the required conformation or regulate their cell surface expression. Sphingolipids can regulate all forms of viral uptake, often through sphingomyelinase activation, and mediate endosomal escape and intracellular trafficking. Ceramide can be key for the formation of viral replication sites. Sphingomyelinases often mediate the release of new virions from infected cells. Moreover, sphingolipids can contribute to viral-induced apoptosis and morbidity in viral diseases, as well as virus immune evasion. Alpha-galactosylceramide, in particular, also plays a significant role in immune modulation in response to viral infections. This review will discuss the roles of ceramide and its related molecules in the different steps of the viral life cycle. We will also discuss how novel strategies could exploit these for therapeutic benefit.
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DOI：
10.3390/v3020102
发表时间：
2011-02
期刊：
Viruses
影响因子：
--
作者：
Avota E;Gassert E;Schneider-Schaulies S
通讯作者：
Schneider-Schaulies S
影响因子：
5.4
作者：
Amako, Yutaka;Sarkeshik, Ali;Siddiqui, Aleem
通讯作者：
Siddiqui, Aleem
DOI：
10.1111/j.1365-2990.1991.tb00727.x
发表时间：
1991-08-01
影响因子：
5
作者：
ATKINS, GJ;MOONEY, DA;SHEAHAN, BJ
通讯作者：
SHEAHAN, BJ
影响因子：
3.7
作者：
Aktepe, Turgut E.;Pham, Helen;Mackenzie, Jason M.
通讯作者：
Mackenzie, Jason M.
影响因子：
6.5
作者：
An Nguyen;Guedan, Anabel;Wakelam, Michael J. O.
通讯作者：
Wakelam, Michael J. O.