Interhemispheric Facilitatory Effect of High-Frequency rTMS: Perspective from Intracortical Facilitation and Inhibition.
Interhemispheric Facilitatory Effect of High-Frequency rTMS: Perspective from Intracortical Facilitation and Inhibition.
复制标题
高频经颅磁刺激的跨半球易化效应：从皮层内易化和抑制的角度。
DOI：
10.3390/brainsci12080970
复制
发表时间：
2022-07-23
期刊：
影响因子：
3.3
通讯作者：
Izumi, Shin-Ichi
中科院分区：
文献类型：
--
作者：
Tian, Dongting;Izumi, Shin-Ichi
关键词：
运动皮层中兴奋性和抑制性神经回路的活动可以通过经颅磁刺激（TMS）和重复TMS（rTMS）无创地探测和修改。目前，不仅对高频rTMS的半球间效应尚未达成共识，而且对这些TMS相关回路的属性也知之甚少。为了全面解决这个问题，我们整合了单脉冲和成对脉冲TMS评估与兴奋性20 Hz rTMS干预，以探讨高频rTMS对皮质内回路的半球间效应。在静息状态下，20-Hz rTMS后，在非刺激半球的单脉冲MEP和成对脉冲皮层内易化（ICF）的显着增加，观察到良好的重测信度。皮质内抑制（测量皮质沉默期）在未受刺激的半球也增加后rTMS。在假手术rTMS组中没有观察到显著的时间过程变化。结果表明，20-Hz rTMS诱导了可靠的纵裂易化效应。本研究结果提示，多巴胺能易化系统和GABA能抑制系统可能同步变化。
The activity of excitatory and inhibitory neural circuits in the motor cortex can be probed and modified by transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS), noninvasively. At present, not only has a consensus regarding the interhemispheric effect of high frequency rTMS not been reached, but the attributes of these TMS-related circuits are also poorly understood. To address this question comprehensively, we integrated a single- and paired-pulse TMS evaluation with excitatory 20-Hz rTMS intervention in order to probe the interhemispheric effect on the intracortical circuits by high-frequency rTMS. In the rest state, after 20-Hz rTMS, a significant increase of single-pulse MEP and paired-pulse intracortical facilitation (ICF) in the non-stimulated hemisphere was observed with good test–retest reliability. Intracortical inhibition (measured by the cortical silent period) in the unstimulated hemisphere also increased after rTMS. No significant time–course change was observed in the sham-rTMS group. The results provide the evidence that 20-Hz rTMS induced a reliable interhemispheric facilitatory effect. Findings from the present study suggest that the glutamatergic facilitatory system and the GABAergic inhibitory system may vary synchronously.
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影响因子：
3.3
作者：
Chaves AR;Snow NJ;Alcock LR;Ploughman M
通讯作者：
Ploughman M
DOI：
10.1016/j.apmr.2004.12.039
发表时间：
2005-08-01
影响因子：
4.3
作者：
Corneal, SF;Butler, AJ;Wolf, SL
通讯作者：
Wolf, SL
影响因子：
2
作者：
Conte, Antonella;Belvisi, Daniele;Berardelli, Alfredo
通讯作者：
Berardelli, Alfredo
影响因子：
4.7
作者：
Jing, HK;Takigawa, M
通讯作者：
Takigawa, M
影响因子：
2
作者：
Cash, R. F. H.;Benwell, N. M.;Thickbroom, G. W.
通讯作者：
Thickbroom, G. W.