Nitric oxide production and absorption in trachea, bronchi, bronchioles, and respiratory bronchioles of humans.
Nitric oxide production and absorption in trachea, bronchi, bronchioles, and respiratory bronchioles of humans.
复制标题
人类气管、支气管、细支气管和呼吸细支气管中一氧化氮的产生和吸收。
DOI:
10.1152/jappl.1999.86.1.159
复制
发表时间:
1999
期刊:
影响因子:
--
通讯作者:
Mohsenin,V
中科院分区:
文献类型:
--
作者:
DuBois,AB;Kelley,PM;Douglas,JS;Mohsenin,V
Different volumes of dead-space gas were collected and analyzed for nitric oxide (NO) content, either immediately after inspiration or after a period of breath holding on clean air or NO mixtures. This allowed calculation of NO equilibrium, NO production, and NO absorption. In seven young, healthy, adult nonsmokers, the mean NO equilibrium values in parts per billion (ppb) were 56 ± 11 (SE) in the trachea, 37 ± 6 in the bronchi, 21 ± 3 in the bronchioles, and 16 ± 2 in the respiratory bronchioles. At any given NO concentration, the NO absorption rate (in nl/min) equaled the NO concentration (in ppb) timesA(the absorption coefficient in l/min).Avalues (in l/min) were 0.11 ± 0.01 in the trachea, 0.17 ± 0.04 in the bronchi, 0.66 ± 0.09 in the bronchioles, and 1.35 ± 0.32 in the respiratory bronchioles. NO equilibrium concentrations and production rates in one 74-yr-old subject were three to five times as high as those found in the young subjects. Mouth equilibrium NO concentrations were 3 and 6 parts per million in two subjects who had oral production rates of 6 and 23 nl/min, respectively. In conclusion, production and absorption of NO occur throughout the first 450 ml of the airways.
登录
查看更多内容
DOI:
10.1152/jappl.1998.84.4.1217
发表时间:
1998
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
Dubois,AB;Douglas,JS;Stitt,JT;Mohsenin,V
通讯作者:
Mohsenin,V
影响因子:
9.6
作者:
Dillon,WC;Hampl,V;Shultz,PJ;Rubins,JB;Archer,SL
通讯作者:
Archer,SL
DOI:
10.1164/ajrccm.154.5.8912750
发表时间:
1996
影响因子:
24.7
作者:
I. Tsujino;K. Miyamoto;M. Nishimura;H. Shinano;H. Makita;Shunichi Saito;Tsuyoshi Nakano;Y. Kawakami
通讯作者:
Y. Kawakami
DOI:
10.1152/jappl.1998.85.4.1203
发表时间:
1998
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
Kelley,PM;DuBois,AB
通讯作者:
DuBois,AB
影响因子:
82.9
作者:
DUNCAN, C;DOUGALL, H;BENJAMIN, N
通讯作者:
BENJAMIN, N