Obesity and Cardiometabolic Defects in Heart Failure Pathology.

Obesity and Cardiometabolic Defects in Heart Failure Pathology.
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DOI:
10.1002/cphy.c170011
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发表时间:
2017-09-12
影响因子:
5.8
通讯作者:
Kain V
Kain V
中科院分区:
医学1区
文献类型:
--
作者:
Halade GV;Kain V

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肥胖是一种主要的全球流行病,它为包括心血管疾病在内的多种疾病奠定了基础。肥胖相关的低级别慢性炎症环境在衰老和心衰病理中对心功能障碍的反应更为明显。肥胖代谢失调与脾肾网络免疫库整合。因此,有必要采用综合系统生物学方法来延缓进行性心脏交替。本文旨在全面探讨肥胖对心血管病理生物学的影响所面临的问题和挑战,重点讨论肥胖的多种模型,并研究肥胖对心脏重塑的影响。这篇文章中的信息对教授高级本科生、研究生和医科学生关于肥胖对心血管健康的进展和影响有很大的帮助。
Obesity is a major global epidemic that sets the stage for diverse multiple pathologies, including cardiovascular disease. The obesity-related low grade chronic inflamed milieu is more pronounced in aging and responsive to cardiac dysfunction in heart failure pathology. Metabolic dysregulation of obesity integrates with immune reservoir in spleen and kidney network. Therefore, an integrative systems biology approach is necessary to delay progressive cardiac alternations. The purpose of this comprehensive review is to largely discuss the impact of obesity on the cardiovascular pathobiology in the context of problems and challenges, with major emphasis on the diversified models, and to study cardiac remodeling in obesity. The information in this article is immensely helpful in teaching advanced undergraduate, graduate, and medical students about the advancement and impact of obesity on cardiovascular health.
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