Obesity and Cardiometabolic Defects in Heart Failure Pathology.
Obesity and Cardiometabolic Defects in Heart Failure Pathology.
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DOI:
10.1002/cphy.c170011
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发表时间:
2017-09-12
影响因子:
5.8
通讯作者:
Kain V
中科院分区:
文献类型:
--
作者:
Halade GV;Kain V
Obesity is a major global epidemic that sets the stage for diverse multiple pathologies, including cardiovascular disease. The obesity-related low grade chronic inflamed milieu is more pronounced in aging and responsive to cardiac dysfunction in heart failure pathology. Metabolic dysregulation of obesity integrates with immune reservoir in spleen and kidney network. Therefore, an integrative systems biology approach is necessary to delay progressive cardiac alternations. The purpose of this comprehensive review is to largely discuss the impact of obesity on the cardiovascular pathobiology in the context of problems and challenges, with major emphasis on the diversified models, and to study cardiac remodeling in obesity. The information in this article is immensely helpful in teaching advanced undergraduate, graduate, and medical students about the advancement and impact of obesity on cardiovascular health.
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