Association Analyses of Autonomic Dysfunction and Sympathetic Skin Response in Motor Subtypes of Parkinson's Disease.
Association Analyses of Autonomic Dysfunction and Sympathetic Skin Response in Motor Subtypes of Parkinson's Disease.
复制标题
帕金森病运动亚型自主神经功能障碍和交感皮肤反应的关联分析。
DOI：
10.3389/fneur.2020.577128
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发表时间：
2020
影响因子：
3.4
通讯作者：
Zhu JH
中科院分区：
文献类型：
--
作者：
Wang JY;Wang MY;Liu RP;Li Y;Zhang WY;Ovlyakulov B;Zhang X;Zhu JH
自主神经功能障碍是帕金森病（PD）常见的致残性非运动症状。我们旨在了解PD运动亚型的自主神经功能障碍，运动不对称的交感皮肤反应（SSR）模式，以及SSR与自主神经和运动功能障碍的关系。方法：选取101例汉族PD患者。对统一PD评定量表（UPDRS）、PD-自主神经症状结局量表（SCOPA-AUT）、直立性低血压和SSR进行评估。结果：位姿不稳定性步态障碍（PIGD）亚型的SCOPA-AUT、直立性低血压和缺失SSR的发生率高于震颤显性和中度亚型。与运动严重程度的加重相对应的SSR潜伏期和振幅不对称。缺少SSR的患者UPDRS和SCOPA-AUT评分较差。SSR患者重症侧SSR参数与评分无独立相关性。结论：我们的研究结果支持自主神经功能障碍在PIGD中比其他亚型更严重，并且显示了SSR在PD患者中的不对称性。缺乏SSR可能表明更严重的自主神经和运动症状，但SSR参数不足以评估功能障碍的严重程度。
Introduction: Autonomic dysfunction is a common and disabling non-motor symptom of Parkinson's disease (PD). We aimed to understand autonomic dysfunction in PD motor subtypes, the pattern of sympathetic skin response (SSR) to motor asymmetry, and the association of SSR with autonomic and motor dysfunctions. Methods: A total of 101 PD patients of Han Chinese were included. Unified PD rating scale (UPDRS), scales for outcomes in PD-autonomic symptoms (SCOPA-AUT), orthostatic hypotension, and SSR were evaluated. Results: SCOPA-AUT and incidences of orthostatic hypotension and absent SSR were worse in the subtype of postural instability gait disorder (PIGD) than the subtypes of tremor dominant and intermediate. SSR latency and amplitude were asymmetrical corresponding to the accentuation of motor severity. Patients with absent SSR had worse UPDRS and SCOPA-AUT scores. SSR parameters of the severe side in patients with SSR showed no independent association with the scores. Conclusion: Our results support that autonomic dysfunction is more severe in the PIGD than other subtypes and demonstrate an asymmetry of SSR in PD patients. Absent SSR may indicate worse autonomic and motor symptoms, but SSR parameters are not sufficient to evaluate the severity of the dysfunctions.
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DOI：
10.4061/2011/967839
发表时间：
2011
期刊：
Parkinson's disease
影响因子：
--
作者：
Bordelon YM;Hays RD;Vassar SD;Diaz N;Bronstein J;Vickrey BG
通讯作者：
Vickrey BG
影响因子：
168.9
作者：
Kalia, Lorraine V.;Lang, Anthony E.
通讯作者：
Lang, Anthony E.
影响因子：
9.9
作者：
JANKOVIC, J;MCDERMOTT, M;WEINER, W
通讯作者：
WEINER, W
影响因子：
8.6
作者：
Allcock, Liesl M.;Kenny, Rose Anne;Burn, David J.
通讯作者：
Burn, David J.
影响因子：
3.3
作者：
Aleksovski, Darko;Miljkovic, Dragana;Antonini, Angelo
通讯作者：
Antonini, Angelo