Genetic and Neurobiological Analyses of the Noradrenergic-like System in Vulnerability to Sugar Overconsumption Using a Drosophila Model.
Genetic and Neurobiological Analyses of the Noradrenergic-like System in Vulnerability to Sugar Overconsumption Using a Drosophila Model.
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DOI：
10.1038/s41598-017-17760-w
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发表时间：
2017-12-15
影响因子：
4.6
通讯作者：
Shen P
中科院分区：
文献类型：
--
作者：
Branch A;Zhang Y;Shen P
经常过量摄入糖与肥胖和 2 型糖尿病有关，但遗传因素如何影响不同的糖偏好和摄入水平仍不清楚。在这里，我们提供了果蝇幼虫模型在研究遗传对糖过度消耗脆弱性的影响方面的有用性的证据。通过遗传和 RNA 干扰方法，我们发现 Oamb 基因（编码章鱼胺（OA，去甲肾上腺素的无脊椎动物同源物）受体）的活性在控制糖消耗方面发挥着重要作用。此外，Oamb 似乎以急性方式抑制进食幼虫的糖类食物摄入，并且表达这种 Oamb 受体的神经元与表达 Octβ3R 的神经元不重叠，Octβ3R 是另一种 OA 受体，之前与饥饿驱动的大量糖摄入有关。总之，这些结果表明，分别由 Oamb 和 Octβ3R 定义的两个独立的子电路根据能量需求的变化共同调节糖的消耗。我们提出，去甲肾上腺素能样系统定义了一种预防糖超载的古老调节机制。
Regular overconsumption of sugar is associated with obesity and type-2 diabetes, but how genetic factors contribute to variable sugar preferences and intake levels remains mostly unclear. Here we provide evidence for the usefulness of a Drosophila larva model to investigate genetic influence on vulnerability to sugar overconsumption. Using genetic and RNA interference approaches, we show that the activity of the Oamb gene, which encodes a receptor for octopamine (OA, the invertebrate homologue of norepinephrine), plays a major role in controlled sugar consumption. Furthermore, Oamb appears to suppress sugar food intake in fed larvae in an acute manner, and neurons expressing this Oamb receptor do not overlap with neurons expressing Octβ3R, another OA receptor previously implicated in hunger-driven exuberant sugar intake. Together, these results suggest that two separate sub-circuits, defined by Oamb and Octβ3R respectively, co-regulate sugar consumption according to changes in energy needs. We propose that the noradrenergic-like system defines an ancient regulatory mechanism for prevention of sugar overload.
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影响因子：
3.3
作者：
Metaxakis, A;Oehler, S;Savakis, C
通讯作者：
Savakis, C
DOI：
10.1073/pnas.0610506104
发表时间：
2007-01-30
影响因子：
11.1
作者：
Barron, Andrew B.;Maleszka, Ryszard;Robinson, Gene E.
通讯作者：
Robinson, Gene E.
影响因子：
5
作者：
GOLDMAN, CK;MARINO, L;LEIBOWITZ, SF
通讯作者：
LEIBOWITZ, SF
影响因子：
2.9
作者：
LEIBOWITZ, SF;BROWN, LL
通讯作者：
BROWN, LL
影响因子：
56.9
作者：
Rulifson, EJ;Kim, SK;Nusse, R
通讯作者：
Nusse, R