Defining dermal adipose tissue.

Defining dermal adipose tissue.
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DOI:
10.1111/exd.12450
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发表时间:
2014-09
影响因子:
3.6
通讯作者:
Horsley V
Horsley V
中科院分区:
医学2区
文献类型:
--
作者:
Driskell RR;Jahoda CA;Chuong CM;Watt FM;Horsley V

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在这里,我们探讨了皮肤相关脂肪组织的演变和发展,目的是建立这种组织的命名。在啮齿动物和人类的网状真皮下,存在一层厚厚的脂肪细胞,包裹着成熟的毛囊。在许多无脊椎动物和脊椎动物物种中发现了脂质填充细胞与皮肤的关联。历史上,这层脂肪细胞被称为皮下脂肪、皮下组织和皮下组织。最近的数据显示,在发育过程中,真皮成纤维细胞和皮内脂肪细胞有一个共同的前体。此外,皮肤中脂肪细胞的发育独立于皮下脂肪组织的发育。最后,脂肪细胞的作用已被证明与毛囊再生和伤口愈合过程中的表皮稳态有关。因此,我们提出了一个精炼的命名为真皮网状层下面的细胞和脂肪组织为皮内脂肪细胞和真皮白色脂肪组织,分别。
Here, we explore the evolution and development of skin-associated adipose tissue with the goal of establishing nomenclature for this tissue. Underlying the reticular dermis, a thick layer of adipocytes exists that encases mature hair follicles in rodents and humans. The association of lipid-filled cells with the skin is found in many invertebrate and vertebrate species. Historically, this layer of adipocytes has been termed subcutaneous adipose, hypodermis, and subcutis. Recent data has revealed a common precursor for dermal fibroblasts and intradermal adipocytes during development. Furthermore, the development of adipocytes in the skin is independent from that of subcutaneous adipose tissue development. Finally, the role of adipocytes has been shown to be relevant for epidermal homeostasis during hair follicle regeneration and wound healing. Thus, we propose a refined nomenclature for the cells and adipose tissue underlying the reticular dermis as intradermal adipocytes and dermal white adipose tissue, respectively.
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