Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents.
Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents.
复制标题
FKBP5 多态性和甲基化以及养育方式与中国青少年抑郁症状的关系
DOI：
10.1186/s12888-021-03576-6
复制
发表时间：
2021-11-09
期刊：
影响因子：
4.4
通讯作者：
Lu C
中科院分区：
文献类型：
--
作者：
Guo L;Wang W;Guo Y;Du X;Shi G;Lu C
背景
Background
Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenting style.
Methods
This study used a nested case-control study design based on a cohort study, and the case (n = 120) and control groups (n = 118) were matched with age. Depressive symptoms, parenting style, and other demographics were measured. Fourteen potential polymorphisms and one promoter region in the FKBP5 gene were selected for genotyping and methylation analysis.
Results
In the adjusted models, a significant association between FKBP5 rs7757037 and depressive symptoms was found in the codominant model (AG vs. GG; adjusted odds ratio [AOR] = 2.56, 95% CI = 1.13–5.78) and dominant model (AA+AG vs. GG; AOR = 2.38, 95% CI = 1.11–5.120); rs2817032 and rs2817035 polymorphisms were associated with depressive symptoms in the codominant model and dominant model. Significant interactions between rs7757037 and the father’s parenting style were found in the codominant model (P = 0.043) and dominant model (P = 0.043), but the gene-environment interactions were not significant after correcting for multiple testing. Moreover, the significant main effects of FKBP5 methylation status on depressive symptoms were not observed, and there was no significant interaction between FKBP5 methylation status and parenting style on depressive symptoms.
Conclusions
Further studies are required to confirm the effect of FKBP5 polymorphisms and methylation as well as their interactions with parenting styles in larger samples.
登录
查看更多内容
影响因子：
6.8
作者：
Corfield EC;Yang Y;Martin NG;Nyholt DR
通讯作者：
Nyholt DR
影响因子：
11
作者：
Colodro-Conde L;Couvy-Duchesne B;Zhu G;Coventry WL;Byrne EM;Gordon S;Wright MJ;Montgomery GW;Madden PAF;Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium;Ripke S;Eaves LJ;Heath AC;Wray NR;Medland SE;Martin NG
通讯作者：
Martin NG
DOI：
10.1002/cd.128
发表时间：
2005-01-01
期刊：
CHANGING BOUNDARIES OF PARENTAL AUTHORITY DURING ADOLESCENCE
影响因子：
--
作者：
Baumrind, Diana
通讯作者：
Baumrind, Diana
影响因子：
6.6
作者：
Kang, Chun;Shi, JunXin;Han, Juan
通讯作者：
Han, Juan
影响因子：
14.9
作者：
Coolen, Marcel W;Statham, Aaron L;Gardiner-Garden, Margaret;Clark, Susan J
通讯作者：
Clark, Susan J