Macrophages in malignant pleural effusions - alternatively activated tumor associated macrophages.
Macrophages in malignant pleural effusions - alternatively activated tumor associated macrophages.
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DOI：
10.5114/wo.2012.30054
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Sikora J
中科院分区：
文献类型：
--
作者：
Kaczmarek M;Sikora J
胸膜巨噬细胞参与了对环境污染、细菌和癌症的局部防御机制。其主要功能包括吞噬变性的间皮细胞。在人类胸腔积液中，巨噬细胞占所有细胞的一半以上。提出了极化巨噬细胞活化（M1和M2）的模型，其定义了响应于发炎环境中存在的各种因素而产生的功能上不同的巨噬细胞群体。肿瘤相关巨噬细胞是大多数癌症的炎性浸润的主要成分。它们可以在癌变的早期阶段和转移期间促进癌细胞的增殖和扩散。从恶性胸腔积液以及肿瘤相关巨噬细胞中分离的巨噬细胞对肿瘤细胞表现出弱的细胞毒活性，增加其增殖活性并可保护肿瘤细胞免于凋亡。确定胸腔积液特定环境中存在的巨噬细胞的生物学特性可以引入创新的诊断和治疗策略。
Pleural macrophages are involved in local defense mechanisms against environmental pollution, bacteria and cancer. Their main function encompasses phagocytosis of degenerated mesothelial cells. In human pleural effusions macrophages represent more than half of all cells. A model of polarized macrophage activation (M1 and M2) was proposed, which defines a functionally different macrophage populations generated in response to various factors present in the inflamed environment. Tumor associated macrophages are a major component of the inflammatory infiltrate of most cancers. They can promote the proliferation and spread of cancer cells in the early stages of carcinogenesis and during metastasis. Macrophages isolated from malignant pleural effusions as well as tumor associated macrophages exhibit weak cytotoxic activity against tumor cells, increase their proliferative activity and may protect tumor cells from apoptosis. Defining biology of macrophages present in specific environment of the pleural effusion could allow the introduction of innovative diagnostic and therapeutic strategies.
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