Chronic inflammation was a major predictor and determinant factor of anemia in lactating women in Sidama zone southern Ethiopia: A cross-sectional study.
Chronic inflammation was a major predictor and determinant factor of anemia in lactating women in Sidama zone southern Ethiopia: A cross-sectional study.
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DOI：
10.1371/journal.pone.0240254
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Stoecker BJ
中科院分区：
文献类型：
--
作者：
Gebreegziabher T;Roice T;Stoecker BJ
育龄妇女贫血在全球范围内非常普遍，仍然是一个公共卫生问题。在埃塞俄比亚，尽管努力尽量减少贫血的负担，但它仍然是一个温和的公共卫生问题。贫血有多种病因，包括营养缺乏、寄生虫感染和炎症。本研究的目的是探讨哺乳期妇女贫血的影响因素。在伦理批准后，分娩后6个月，从8个随机选择的农村村庄招募所有哺乳期妇女（n = 150）参加本研究。人体测量和社会经济因素进行了评估。从每一个人身上采集血样，用于测量血红蛋白、铁生物标志物、锌、硒和炎症标志物。中位（IQR）血红蛋白（Hb）为132（123，139）g/L。在这些妇女中，19%贫血，7%缺铁性贫血; 31%缺铁，2%铁超载。此外，8%有功能性缺铁，6%有急性炎症，13%有慢性炎症，16%有组织缺铁。大多数（78%）的女性血浆锌水平较低，其中超过16%的女性贫血。Hb与血浆铁、锌呈正相关，与转铁蛋白受体（TfR）、α-1-酸性糖蛋白（AGP）呈负相关。血浆铁、AGP、TfR、铁调素和血浆锌是孕妇贫血的重要预测因子。此外，MUAC和教育水平与母亲血红蛋白呈正相关。这项研究表明，母亲贫血与多种因素有关，包括营养缺乏，炎症和教育程度有限。
Anemia in women of reproductive age is highly prevalent globally and remains a public health problem. In Ethiopia, despite efforts to minimize the burden of anemia, it is still a moderate public health problem. Anemia has various etiologies including nutritional deficiency, parasitic infection, and inflammation. The aim of this study was to examine contributing factors to anemia in lactating women. Following ethical approval, and six months after delivery, all lactating women (n = 150) were recruited to participate in this study from eight randomly selected rural villages. Anthropometric and socio-economic factors were assessed. From each, a blood sample was collected for measuring hemoglobin, iron biomarkers, zinc, selenium, and inflammation markers. The median (IQR) hemoglobin (Hb) was 132 (123, 139) g/L. Of the women, 19% were anemic and 7% had iron deficiency anemia; 31% were iron deficient and 2% had iron overload. Also, 8% had functional iron deficit, 6% had acute inflammation, 13% had chronic inflammation, and 16% had tissue iron deficiency. The majority (78%) of the women had low plasma zinc out of which more than 16% were anemic. Hb was positively associated with plasma iron and plasma zinc and negatively associated with transferrin receptor (TfR) and α-1-acid glycoprotein (AGP). Plasma iron, AGP, TfR, hepcidin and plasma zinc were significant predictors of maternal anemia. Additionally MUAC and level of education were associated positively with maternal hemoglobin. This study showed that maternal anemia was associated with multiple factors including nutritional deficiencies, inflammation and limited education.
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影响因子：
4.2
作者：
Haas, JD;Brownlie, T
通讯作者：
Brownlie, T
影响因子：
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作者：
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