A novel polysaccharide from Rhizoma panacis japonica exerts anti-inflammatory effects via STAT3 signal pathway.
A novel polysaccharide from Rhizoma panacis japonica exerts anti-inflammatory effects via STAT3 signal pathway.
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DOI：
10.1039/c8ra02923g
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发表时间：
2018-07-19
期刊：
影响因子：
3.9
通讯作者：
He, Wei
中科院分区：
文献类型：
--
作者：
Li, Qiu;Li, Qun;Hao, Zhihui;Zheng, Xucai;He, Wei
本文报道了一种新的具有抗炎活性的水溶性多糖PJ-1。我们首先用水洗脱从该草药中获得多糖。在用一系列色谱技术充分表征PJ-1后，我们通过刺激Raw 264.7细胞表达炎性细胞因子来评估其生物活性，发现PJ-1有效地增强了抗炎因子如IL-10的产生。我们进一步确定了其在脂多糖诱导的脓毒症小鼠模型中的抗炎作用。PJ-1治疗明显抑制了主要炎性细胞因子的分泌，提高了小鼠的存活率。特别地，我们验证了负责抗炎活性的STAT 3信号通路。因此，PJ-1具有显著的抗炎作用和作用机制，可能是一种有希望的抗炎药物候选者。PJ-1通过STAT 3信号通路调节巨噬细胞的功能。
We report a novel water-soluble polysaccharide from Rhizoma panacis japonica, namely, PJ-1 with anti-inflammatory activity. We first obtained a polysaccharide from this herb by eluting with water. After fully characterizing PJ-1 with a series of chromatographic technologies, we evaluated its biological activity by stimulating Raw 264.7 cells to express inflammatory cytokines and found that PJ-1 effectively enhanced the production of anti-inflammatory factors such as IL-10. We further identified its anti-inflammatory effect in a mouse model of sepsis induced by a lipopolysaccharide. The treatment of PJ-1 evidently suppressed the secretion of major inflammatory cytokines and increased the survival rate of mice. Particularly, we verified the STAT3 signal pathway responsible for the anti-inflammatory activity. Thus, PJ-1, which has remarkable anti-inflammatory effect and mechanism of action, may be a promising candidate as an anti-inflammatory agent. PJ-1 modulates the function of macrophages via the STAT3 signal pathway.
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