Corollary discharge prevents signal distortion and enhances sensing during locomotion
Corollary discharge prevents signal distortion and enhances sensing during locomotion
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伴随放电可防止信号失真并增强运动过程中的感测
DOI：
10.1101/2021.02.15.431323
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Liao*, James C.
中科院分区：
文献类型：
--
作者：
Skandalis, *;Lunsford, Elias T.;Liao*, James C.
运动过程中的感觉反馈需要感知外部和自我产生的刺激（分别为外传入和内传入）的混合。在许多外周感觉系统中，运动指令的平行复制，一种必然的放电，被认为可以消除行为过程中的感觉反馈。然而，反馈在运动控制中起着重要的作用，因为它提供了动物在环境中运动的实时反馈。在这种情况下，必须校准相应的放电，以实现反馈，同时避免传感器疲劳等负面后果。鱼类身体的波动运动产生诱导流，这些诱导流被侧线感觉器官感觉到，并且先前的工作表明这些传入信号有助于游泳运动学的调节。对侧线的推论放电减少了反射的增益，但不能完全消除它。我们开发了一个数据驱动的模型，整合游泳生物力学，毛细胞生理学和必然的放电，以了解如何在运动过程中校准的感觉调制在幼斑马鱼。在没有必然放电的情况下，侧线传入单位表现出高度异质性的习惯率特征的毛细胞系统，典型的衰减灵敏度和相位失真相对于输入刺激。激活的必然放电防止习惯化，减少反应的异质性，并在一个狭窄的时间间隔内调节反应阶段的峰值刺激的时间。这表明了一个协同效应之间的相互作用的必然放电和极化的侧线传感器，锐化灵敏度沿着他们的首选轴。我们的综合模型揭示了一个重要的作用，必然放电，以确保精确的反馈，包括本体感觉，在波动运动。
Sensory feedback during movement entails sensing a mix of externally- and self-generated stimuli (respectively, exafference and reafference). In many peripheral sensory systems, a parallel copy of the motor command, a corollary discharge, is thought to eliminate sensory feedback during behaviors. However, reafference has important roles in motor control, because it provides real-time feedback on the animal’s motions through the environment. In this case, the corollary discharge must be calibrated to enable feedback while avoiding negative consequences like sensor fatigue. The undulatory motions of fishes’ bodies generate induced flows that are sensed by the lateral line sensory organ, and prior work has shown these reafferent signals contribute to the regulation of swimming kinematics. Corollary discharge to the lateral line reduces the gain for reafference, but cannot eliminate it altogether. We develop a data-driven model integrating swimming biomechanics, hair cell physiology, and corollary discharge to understand how sensory modulation is calibrated during locomotion in larval zebrafish. In the absence of corollary discharge, lateral line afferent units exhibit the highly heterogeneous habituation rates characteristic of hair cell systems, typified by decaying sensitivity and phase distortions with respect to an input stimulus. Activation of the corollary discharge prevents habituation, reduces response heterogeneity, and regulates response phases in a narrow interval around the time of the peak stimulus. This suggests a synergistic interaction between the corollary discharge and the polarization of lateral line sensors, which sharpens sensitivity along their preferred axes. Our integrative model reveals a vital role of corollary discharge for ensuring precise feedback, including proprioception, during undulatory locomotion.
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影响因子：
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DOI：
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影响因子：
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