Auditory brainstem development and plasticity.

Auditory brainstem development and plasticity.
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DOI:
10.1016/j.cophys.2020.07.002
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发表时间:
2020-12
影响因子:
2.5
通讯作者:
Rubio ME
Rubio ME
中科院分区:
其他
文献类型:
--
作者:
Rubio ME

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在发育和成年期,听神经的正常活动对维持听神经突触的基本结构、分子和功能参数以及耳蜗核内突触后兴奋性或抑制性神经元起着至关重要的作用。此外,CN突触回路内的正常活动是发展和维持适当的突触连接以及启动上橄榄复合体(SOC)双耳声音处理的关键。发育对神经元的正确连接起着至关重要的作用,并沿着整个听觉通路建立地形图。此外,有证据表明,听觉脑干中的神经元和突触电路并不是硬连接的,而是对听力障碍做出反应的可塑性。这种对听力损失的可塑性是代偿性的,还是病理性的,目前尚不清楚。
During development and adulthood, the normal activity of the auditory nerve plays a critical role in the maintenance of both fundamental structural, molecular, and functional parameters of auditory nerve synapses, and the postsynaptic excitatory or inhibitory neurons within the cochlear nucleus (CN). In addition, normal activity within the synaptic circuits of the CN is key to developing and maintaining appropriate synapse connectivity as well as the initiation of binaural sound processing in the superior olivary complex (SOC). Development plays a critical role in the proper neuronal connectivity and establishes a topographic map along the entire auditory pathway. Furthermore, evidence shows that neurons and synaptic circuits in the auditory brainstem are not hard-wired, but instead are plastic in response to hearing deficits. Whether this plasticity in response to hearing loss is compensatory or pathological is still unknown.
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