Crosstalk between perivascular adipose tissue and blood vessels.
Crosstalk between perivascular adipose tissue and blood vessels.
复制标题
血管周围脂肪组织和血管之间的串扰。
DOI：
10.1016/j.coph.2009.11.005
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发表时间：
2010-04
影响因子：
4
通讯作者：
Weintraub, Neal L.
中科院分区：
文献类型：
--
作者：
Rajsheker, Srinivas;Manka, David;Blomkalns, Andra L.;Chatterjee, Tapan K.;Stoll, Lynn L.;Weintraub, Neal L.
血管壁细胞之间的串扰对正常的血管功能至关重要，在动脉粥样硬化和高血压等疾病中会受到干扰。血管周围脂肪细胞位于血管的外膜边缘，但直到最近在血管功能的研究中几乎被忽视。然而，血管周围脂肪细胞已被证明是强大的内分泌细胞，能够对代谢信号做出反应，并将信号传递给邻近的血管。因此，血管周围脂肪组织(PVAT)和血管之间的串扰现在正受到密切关注。新出现的证据表明，PVAT通过多种机制调节血管功能，但迄今为止的证据表明，PVAT对三个关键方面的调节是本综述的重点：炎症、血管反应性和平滑肌细胞增殖。
Crosstalk between cells in the blood vessel wall is vital to normal vascular function and is perturbed in diseases such as atherosclerosis and hypertension. Perivascular adipocytes reside at the adventitial border of blood vessels but until recently were virtually ignored in studies of vascular function. However, perivascular adipocytes have been demonstrated to be powerful endocrine cells capable of responding to metabolic cues and transducing signals to adjacent blood vessels. Accordingly, crosstalk between perivascular adipose tissue (PVAT) and blood vessels is now being intensely examined. Emerging evidence suggests that PVAT regulates vascular function through numerous mechanisms, but evidence to date suggests modulation of three key aspects that are the focus of this review: inflammation, vasoreactivity, and smooth muscle cell proliferation.
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影响因子：
20.1
作者：
Chatterjee TK;Stoll LL;Denning GM;Harrelson A;Blomkalns AL;Idelman G;Rothenberg FG;Neltner B;Romig-Martin SA;Dickson EW;Rudich S;Weintraub NL
通讯作者：
Weintraub NL
影响因子：
6.7
作者：
Braunersreuther, Vincent;Mach, Francois;Steffens, Sabine
通讯作者：
Steffens, Sabine
DOI：
10.1073/pnas.0601752103
发表时间：
2006-04-25
影响因子：
11.1
作者：
Gesta, S;Blüher, M;Kahn, CR
通讯作者：
Kahn, CR
影响因子：
37.8
作者：
Mazurek, T;Zhang, LF;Shi, Y
通讯作者：
Shi, Y
影响因子：
56.9
作者：
LARSEN, CG;ANDERSON, AO;MATSUSHIMA, K
通讯作者：
MATSUSHIMA, K