Cardiovascular, hormonal, and emotional responses to the TSST in relation to sex and menstrual cycle phase.

Cardiovascular, hormonal, and emotional responses to the TSST in relation to sex and menstrual cycle phase.
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DOI:
10.1111/j.1469-8986.2009.00961.x
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发表时间:
2010-05-01
期刊:
影响因子:
3.7
通讯作者:
De Wit H
De Wit H
中科院分区:
心理学3区
文献类型:
--
作者:
Childs E;Dlugos A;De Wit H

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男性和女性的应激障碍患病率不同。了解男性和女性在急性应激反应中的差异可能有助于理解这些性别差异。我们比较了健康男性 (N=28) 和在月经周期的两个阶段 (卵泡 N=29,黄体 N=23) 测试的女性对 TSST 和对照任务的反应。在这两个阶段,男性对压力的皮质醇反应都比女性更强。黄体女性对压力表现出最大的主观反应和四氢孕酮反应,而卵泡女性则表现出去甲肾上腺素反应减弱。控制群体差异的部分相关性显示,对压力主观影响最敏感的个体表现出最大的唾液皮质醇、去甲肾上腺素和四氢孕酮反应,以及最小的黄体酮对压力的反应。我们在压力相关疾病患病率的性别差异的背景下讨论我们的发现。
The prevalence of stress disorders differs between men and women. An understanding of how men and women vary in acute stress responses may help to understand these sex differences. We compared responses to the TSST and a control task in healthy men (N=28) and women tested in two phases (Follicular N=29, Luteal N=23) of the menstrual cycle. Men exhibited greater cortisol responses to stress than women in either phase. Luteal women exhibited the greatest subjective and allopregnanolone responses to stress, whereas follicular women exhibited blunted noradrenaline responses. Partial correlations controlling for group differences revealed that individuals who were most sensitive to the subjective effects of stress exhibited the largest salivary cortisol, noradrenaline, and allopregnanolone responses and the smallest progesterone responses to stress. We discuss our findings in the context of sex differences in the prevalence of stress-linked disorders.
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