The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis.
The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis.
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DOI：
10.1016/j.ydbio.2012.11.004
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发表时间：
2013-01-15
影响因子：
2.7
通讯作者：
Fuller, Margaret T.
中科院分区：
文献类型：
--
作者：
Davies, Erin L.;Lim, Jaclyn G. Y.;Joo, William J.;Tam, Cheuk Ho;Fuller, Margaret T.
干细胞的行为受到来自特定微环境或小生境的外在信号和执行对小生境信号的上下文适当响应所需的内在因素的调节。在这里，我们表明，功能的转录调节子的缺乏（lola）是所需的细胞自主生殖干细胞和体细胞囊肿干细胞的维持在果蝇睾丸。此外，在雄性生殖细胞分化过程中，lola也是正确执行关键发育转变所必需的，包括从运输扩增祖细胞到精母细胞生长和分化的转换，以及减数分裂细胞周期的进展和精子发生。不同的lola同种型，每个具有独特的C-末端和锌指结构域，可以控制不同方面的增殖和分化的雄性生殖系和体细胞囊肿干细胞谱系。
Stem cell behavior is regulated by extrinsic signals from specialized microenvironments, or niches, and intrinsic factors required for execution of context-appropriate responses to niche signals. Here we show that function of the transcriptional regulator longitudinals lacking (lola) is required cell autonomously for germline stem cell and somatic cyst stem cell maintenance in the Drosophila testis. In addition, lola is also required for proper execution of key developmental transitions during male germ cell differentiation, including the switch from transit amplifying progenitor to spermatocyte growth and differentiation, as well as meiotic cell cycle progression and spermiogenesis. Different lola isoforms, each having unique C-termini and zinc finger domains, may control different aspects of proliferation and differentiation in the male germline and somatic cyst stem cell lineages.
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