Sex-specific associations between body mass index, waist circumference and the risk of Barrett's oesophagus: a pooled analysis from the international BEACON consortium.
Sex-specific associations between body mass index, waist circumference and the risk of Barrett's oesophagus: a pooled analysis from the international BEACON consortium.
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DOI：
10.1136/gutjnl-2012-303753
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发表时间：
2013-12
期刊：
影响因子：
24.5
通讯作者：
Corley DA
中科院分区：
文献类型：
--
作者：
Kubo A;Cook MB;Shaheen NJ;Vaughan TL;Whiteman DC;Murray L;Corley DA
巴雷特食管是食管腺癌的前驱病变，在美国，在过去40年中，食管腺癌的发病率增加了600%以上。Barrett食管和食管腺癌在男性中比女性更常见;这一发现无法解释，大多数早期研究缺乏足够数量的女性来评估性别特异性风险因素。我们利用国际联盟的力量来评估体重指数（BMI），腹围和巴雷特食管之间的性别特异性关系。四项病例对照研究共提供了1102例病例（316例女性，786例男性）和1400例人群对照（436例女性，964例男性）进行分析。使用个体参与者数据生成的研究特定估计值使用随机效应荟萃分析进行合并。腰围与Barrett食管显著相关，即使在调整BMI后也是如此;腰围最高与最低四分位数的人在男性和女性中Barrett食管的几率分别增加了约125%和275%。（OR 2.24，95% CI 1.08至4.65，I2=57; OR 3.75，95% CI 1.47至9.56，I2=0）。相比之下，没有证据表明BMI与Barrett食管风险之间存在显著相关性，无论是否调整腰围。腰围，独立于BMI，被发现是男性和女性中巴雷特食管的危险因素。未来的研究探讨这种关联的生物学机制将扩大我们对巴雷特食管发病机制的认识。
Barrett’s oesophagus is a precursor lesion of oesophageal adenocarcinoma, a cancer that, in the USA, has increased in incidence over 600% during the past 40 years. Barrett’s oesophagus and oesophageal adenocarcinoma are much more common among men than among women; this finding is unexplained and most earlier studies lacked sufficient numbers of women to evaluate sex-specific risk factors. We leveraged the power of an international consortium to assess sex-specific relationships between body mass index (BMI), abdominal circumference and Barrett’s oesophagus. Four case–control studies provided a total of 1102 cases (316 women, 786 men) and 1400 population controls (436 women, 964 men) for analysis. Study-specific estimates, generated using individual participant data, were combined using random effects meta-analysis. Waist circumference was significantly associated with Barrett’s oesophagus, even after adjustment for BMI; persons in the highest versus the lowest quartiles of waist circumference had approximately 125% and 275% increases in the odds of Barrett’s oesophagus among men and women, respectively (OR 2.24, 95% CI 1.08 to 4.65, I2=57; OR 3.75, 95% CI 1.47 to 9.56, I2=0). In contrast, there was no evidence of a significant association between BMI and the risk of Barrett’s oesophagus, with or without adjustment for waist circumference. Waist circumference, independent of BMI, was found to be a risk factor for Barrett’s oesophagus among both men and women. Future studies examining the biological mechanisms of this association will extend our knowledge regarding the pathogenesis of Barrett’s oesophagus.
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DOI：
10.1016/j.numecd.2009.02.006
发表时间：
2010-01
期刊：
Nutrition, metabolism, and cardiovascular diseases : NMCD
影响因子：
--
作者：
Agnoli C;Berrino F;Abagnato CA;Muti P;Panico S;Crosignani P;Krogh V
通讯作者：
Krogh V
影响因子：
9.6
作者：
Beddy, P.;Howard, J.;Keogan, M. T.
通讯作者：
Keogan, M. T.
影响因子：
9.8
作者：
El-Serag, HB;Kvapil, P;Kramer, JR
通讯作者：
Kramer, JR
影响因子：
29.4
作者：
Cook, Michael B.;Shaheen, Nicholas J.;Corley, Douglas A.
通讯作者：
Corley, Douglas A.
影响因子：
5
作者：
Olsen, Catherine M.;Pandeya, Nirmala;Whiteman, David C.
通讯作者：
Whiteman, David C.