Development of brain mechanisms for processing affective touch.
Development of brain mechanisms for processing affective touch.
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DOI：
10.3389/fnbeh.2014.00024
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发表时间：
2014
影响因子：
3
通讯作者：
Kaiser MD
中科院分区：
文献类型：
--
作者：
Björnsdotter M;Gordon I;Pelphrey KA;Olausson H;Kaiser MD
情感触觉刺激在神经回路的成熟中起着关键作用，但对处理触觉的大脑机制的发展知之甚少。因此，我们使用功能性磁共振成像（fMRI）来研究健康儿童（5-13岁），青少年（14-17岁）和成人（25-35岁）对无毛（手掌）和有毛（前臂）皮肤的软刷抚摸的大脑反应。在所有年龄组中，成人定义的初级体感皮质（SI）、次级体感皮质（SII）、岛叶皮质和右后颞上沟（pSTS）的感兴趣区域均被显着且相似地激活。上级颞沟。全脑分析显示，在同侧SII的反应与年龄呈正相关，在两种性别，并在双边地区附近的pSTS的反应相关性显着，强烈与年龄的女性，但不是在男性。这些结果表明，大脑机制与感官歧视和情感动机方面的触摸主要建立在学龄儿童，并有一个普遍的持续成熟的SII和女性特定的增加pSTS敏感性随年龄的增长。我们的工作建立了一个基础，为未来的比较研究触觉处理的发展障碍的特点是破坏社会知觉，如自闭症。
Affective tactile stimulation plays a key role in the maturation of neural circuits, but the development of brain mechanisms processing touch is poorly understood. We therefore used functional magnetic resonance imaging (fMRI) to study brain responses to soft brush stroking of both glabrous (palm) and hairy (forearm) skin in healthy children (5–13 years), adolescents (14–17 years), and adults (25–35 years). Adult-defined regions-of-interests in the primary somatosensory cortex (SI), secondary somatosensory cortex (SII), insular cortex and right posterior superior temporal sulcus (pSTS) were significantly and similarly activated in all age groups. Whole-brain analyses revealed that responses in the ipsilateral SII were positively correlated with age in both genders, and that responses in bilateral regions near the pSTS correlated significantly and strongly with age in females but not in males. These results suggest that brain mechanisms associated with both sensory-discriminative and affective-motivational aspects of touch are largely established in school-aged children, and that there is a general continuing maturation of SII and a female-specific increase in pSTS sensitivity with age. Our work establishes a groundwork for future comparative studies of tactile processing in developmental disorders characterized by disrupted social perception such as autism.
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影响因子：
5.3
作者：
Bjornsdotter, Malin;Loken, Line;Wessberg, Johan
通讯作者：
Wessberg, Johan
影响因子：
2
作者：
Kaiser, Martha D.;Shiffrar, Maggie;Pelphrey, Kevin A.
通讯作者：
Pelphrey, Kevin A.
影响因子：
9.2
作者：
Fabrizi, Lorenzo;Slater, Rebeccah;Worley, Alan;Meek, Judith;Boyd, Stewart;Olhede, Sofia;Fitzgerald, Maria
通讯作者：
Fitzgerald, Maria
影响因子：
3.7
作者：
Kurth, Florian;Eickhoff, Simon B.;Amunts, Katrin
通讯作者：
Amunts, Katrin
影响因子：
5.7
作者：
Bonte, Milene;Frost, Martin A.;Goebel, Rainer
通讯作者：
Goebel, Rainer