Can bilingualism increase neuroplasticity of language networks in epilepsy?
Can bilingualism increase neuroplasticity of language networks in epilepsy?
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DOI：
10.1016/j.eplepsyres.2022.106893
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发表时间：
2022-05
影响因子：
2.2
通讯作者：
McDonald, Carrie R.
中科院分区：
文献类型：
--
作者：
Stasenko, Alena;Schadler, Adam;Kaestner, Erik;Reyes, Anny;Diaz-Santos, Mirella;Polczynska, Monika;McDonald, Carrie R.
关键词：
患有左颞叶癫痫（TLE）的个体具有更高的非典型（即，双侧或右半球）语言偏侧化。此外，双语者被观察到具有较少的语言表征的左侧化模式。我们研究了双语语言经验和癫痫侧集中在TLE语言侧化配置文件的综合影响，以确定是否双语促进语言网络的重组。72个单语英语（21左颞叶; LTLE，22右颞叶; RTLE，29年龄匹配的健康对照; HC）和24英语占主导地位的双语（6 LTLE，7 RTLE，11 HC）完成了词汇语义功能MRI任务和标准化措施的语言英语。语言偏侧化的确定使用偏侧指数的基础上激活左与右同源的侧裂周围区的利益（ROI）。在额颞ROI，LTLE显示出预期的模式较弱的左语言偏侧相对于HC，和单语者表现出较弱的左语言偏侧相对于双语者的趋势。重要的是，这些影响是合格的一个显着的组语言状态的相互作用，揭示了双语LTLE有更大的语言偏侧化相对于单语LTLE，特别是在侧颞区的大的效果大小。在双语LTLE中，右侧语言偏侧化与更好的语言成绩相关。这些初步的研究结果表明，双语语言的经验和左半球的神经损伤，这可能会共同增加语言重组到右半球的可能性的综合影响。我们的数据强调需要考虑双语作为一个重要因素，有助于语言偏侧性TLE患者。双语可能在术前具有神经保护作用，并可能减轻左前颞叶切除术后的术后语言下降，这对于在更大样本中进行测试非常重要。
Individuals with left temporal lobe epilepsy (TLE) have a higher rate of atypical (i.e., bilateral or right hemisphere) language lateralization compared to healthy controls. In addition, bilinguals have been observed to have a less left-lateralized pattern of language representation. We examined the combined influence of bilingual language experience and side of seizure focus on language lateralization profiles in TLE to determine whether bilingualism promotes re-organization of language networks. Seventy-two monolingual speakers of English (21 left TLE; LTLE, 22 right TLE; RTLE, 29 age-matched healthy controls; HC) and 24 English-dominant bilinguals (6 LTLE, 7 RTLE, 11 HC) completed a lexical-semantic functional MRI task and standardized measures of language in English. Language lateralization was determined using laterality indices based on activations in left vs right homologous perisylvian regions-of-interest (ROIs). In a fronto-temporal ROI, LTLE showed the expected pattern of weaker left language lateralization relative to HC, and monolinguals showed a trend of weaker left language lateralization relative to bilinguals. Importantly, these effects were qualified by a significant group by language status interaction, revealing that bilinguals with LTLE had greater rightward language lateralization relative to monolingual LTLE, with a large effect size particularly in the lateral temporal region. Rightward language lateralization was associated with better language scores in bilingual LTLE. These preliminary findings suggest a combined effect of bilingual language experience and a left hemisphere neurologic insult, which may together increase the likelihood of language re-organization to the right hemisphere. Our data underscore the need to consider bilingualism as an important factor contributing to language laterality in patients with TLE. Bilingualism may be neuroprotective pre-surgically and may mitigate post-surgical language decline following left anterior temporal lobectomy, which will be important to test in larger samples.
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影响因子：
5.6
作者：
Binder, Jeffrey R.;Sabsevitz, David S.;Mueller, Wade M.
通讯作者：
Mueller, Wade M.
影响因子：
3.4
作者：
Bartha-Doering, Lisa;Bonelli, Silvia
通讯作者：
Bonelli, Silvia
影响因子：
2.4
作者：
Cheung, Mei-chun;Chan, Agnes S.;Lam, Joseph M. K.
通讯作者：
Lam, Joseph M. K.
DOI：
10.1017/s1355617721001004
发表时间：
2022-09
期刊：
Journal of the International Neuropsychological Society : JINS
影响因子：
--
作者：
Garcia DL;Gollan TH
通讯作者：
Gollan TH
DOI：
10.1017/s135561770393013x
发表时间：
2003-03-01
影响因子：
2.6
作者：
Hamberger, MJ;Seidel, WT
通讯作者：
Seidel, WT