Uteroplacental insufficiency alters rat hippocampal cellular phenotype in conjunction with ErbB receptor expression.
Uteroplacental insufficiency alters rat hippocampal cellular phenotype in conjunction with ErbB receptor expression.
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DOI：
10.1038/pr.2012.32
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发表时间：
2012-07
影响因子：
3.6
通讯作者：
Lane, Robert H.
中科院分区：
文献类型：
--
作者：
Fung, Camille;Ke, Xingrao;Brown, Ashley S.;Yu, Xing;McKnight, Robert A.;Lane, Robert H.
子宫胎盘功能不全(UPI)会导致严重的神经发育缺陷，影响宫内生长受限(IUGR)后代的海马区。IUGR男性的缺陷比IUGR女性更严重。这些赤字背后的确切机制尚不清楚。海马区细胞成分的改变以及神经干细胞(NSC)分化分子表达的改变可能是这些缺陷的基础。我们假设IUGR海马会在出生时具有改变的神经元、星形胶质细胞和未成熟的少突胶质细胞的比例，男性表现出更大的细胞缺陷。我们进一步假设UPI会在出生时和断奶时干扰大鼠海马区ErbB受体(ErbB-Rs)和神经调节蛋白1(NRG1)的表达，以解释IUGR神经的短期和长期后遗症。建立大鼠胚胎19.5天双侧子宫动脉结扎模型，建立IUGR模型。与性别匹配的对照组相比，IUGR后代在出生时改变了海马神经元、星形胶质细胞和未成熟的少突胶质细胞的组成--以及性别特有的方式。此外，IUGR海马区在出生时和断奶时改变了受体类型和性别特异性ErbB-R的表达。这些细胞和分子的改变可能解释了IUGR的神经发育并发症和男性对较差的神经结局的易感性。
Uteroplacental insufficiency (UPI) produces significant neurodevelopmental deficits affecting the hippocampus of intrauterine growth restricted (IUGR) offspring. IUGR males have worse deficits compared to IUGR females. The exact mechanisms underlying these deficits are unclear. Alterations in hippocampal cellular composition along with altered expression of neural stem cell (NSC) differentiation molecules may underlie these deficits. We hypothesized that IUGR hippocampi would be endowed with altered neuronal, astrocytic, and immature oligodendrocytic proportions at birth, with males showing greater cellular deficits. We further hypothesized that UPI would perturb rat hippocampal expression of ErbB receptors (ErbB-Rs) and Neuregulin 1 (NRG1) at birth and at weaning to account for the short- and long-term IUGR neurological sequelae. A well established rat model of bilateral uterine artery ligation at embryonic day (E) 19.5 was used to induce IUGR. Compared to gender-matched controls, IUGR offspring have altered hippocampal neuronal, astrocytic, and immature oligodendrocytic composition in a subregion- and gender-specific manner at birth. In addition, IUGR hippocampi have altered receptor-type- and gender-specific ErbB-R expression at birth and at weaning. These cellular and molecular alterations may account for the neurodevelopmental complications of IUGR and for the male susceptibility to worse neurologic outcomes.
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DOI：
10.1016/j.ijdevneu.2008.06.004
发表时间：
2008-11-01
影响因子：
1.8
作者：
Chong, Victor Z.;Webster, Maree J.;Weickert, Cynthia Shannon
通讯作者：
Weickert, Cynthia Shannon
影响因子：
3.6
作者：
Lodygensky, Gregory A.;Seghier, Mohammed L.;Hueppi, Petra S.
通讯作者：
Hueppi, Petra S.
影响因子：
2.5
作者：
ALTMAN, J;BAYER, SA
通讯作者：
BAYER, SA
影响因子：
2.9
作者：
Lane, RH;Ramirez, RJ;Devaskar, SU
通讯作者：
Devaskar, SU
影响因子：
64.8
作者：
GASSMANN, M;CASAGRANDA, F;LEMKE, G
通讯作者：
LEMKE, G