Active and passive smoking and the risk of myocardial infarction in 24,968 men and women during 11 year of follow-up: the Tromsø Study.
Active and passive smoking and the risk of myocardial infarction in 24,968 men and women during 11 year of follow-up: the Tromsø Study.
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DOI：
10.1007/s10654-013-9785-z
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发表时间：
2013-08
影响因子：
13.6
通讯作者：
Lochen, Maja-Lisa
中科院分区：
文献类型：
--
作者：
Iversen, Birgitte;Jacobsen, Bjarne K.;Lochen, Maja-Lisa
主动吸烟是心肌梗死的一个公认的危险因素，但对被动吸烟的影响知之甚少，以及与被动吸烟相关的风险可能存在的性别差异。我们对特罗姆瑟研究中的11762名男性和13206名女性进行了为期11年的随访，调查了主动和被动吸烟作为心肌梗死的危险因素。男性和女性分别有769例和453例心肌梗死事件。我们发现主动吸烟和被动吸烟与男女心肌梗死发病率之间存在年龄调整后的线性关系。这种关系在女性中似乎比在男性中更强。年龄调整分析表明，与从不吸烟者相比，曾经吸烟者与被动吸烟的关系更强。在调整了重要混杂因素（体重指数、血压、总胆固醇、高密度脂蛋白胆固醇和体力活动）后，主动吸烟和被动吸烟的相关性仍然具有统计学意义。在评估被动吸烟的影响时调整主动吸烟，反之亦然，表明男性被动吸烟的影响可能由他们自己的主动吸烟来解释。在女性中，20岁后与吸烟者生活≥30年的心肌梗死风险增加40%，即使在调整积极吸烟因素后也是如此。被动吸烟本身就是心肌梗死的一个危险因素，但对男性的影响似乎可以用他们自己的主动吸烟来解释，而对女性的影响在统计上仍然是显著的。
Active smoking is a well-established risk factor for myocardial infarction, but less is known about the impact of passive smoking, and possible sex differences in risk related to passive smoking. We investigated active and passive smoking as risk factors for myocardial infarction in an 11-year follow-up of 11,762 men and 13,206 women included in the Tromsø Study. There were a total of 769 and 453 incident cases of myocardial infarction in men and women, respectively. We found linear age-adjusted relationships between both active and passive smoking and myocardial infarction incidence in both sexes. The relationships seem to be stronger for women than for men. Age-adjusted analyses indicated a stronger relationship with passive smoking in ever-smokers than in never-smokers. After adjustment for important confounders (body mass index, blood pressure, total cholesterol, HDL cholesterol and physical activity) the associations with active and passive smoking were still statistically significant. Adjusting for active smoking when assessing the effect of passive smoking and vice versa, indicated that the effect of passive smoking in men may be explained by their own active smoking. In women, living with a smoker ≥30 years after the age of 20 increased the myocardial infarction risk by 40 %, even after adjusting for active smoking. Passive smoking is a risk factor for myocardial infarction on its own, but whereas the effect for men seems to be explained by their own active smoking, the effect in females remains statistically significant.
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影响因子：
5.8
作者：
Azziz, R;Woods, KS;Yildiz, BO
通讯作者：
Yildiz, BO
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Knudsen, Ann Kristin;Hotopf, Matthew;Mykletun, Arnstein
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Mykletun, Arnstein
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Langhammer, Arnulf;Krokstad, Steinar;Holmen, Jostein
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Holmen, Jostein
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通讯作者：
Whelton, PK
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通讯作者：
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