In vivo efficacy of calcium phosphate-based synthetic-bone-mineral on bone loss resulting from estrogen and mineral deficiencies.
In vivo efficacy of calcium phosphate-based synthetic-bone-mineral on bone loss resulting from estrogen and mineral deficiencies.
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基于磷酸钙的合成骨矿物质对雌激素和矿物质缺乏引起的骨质流失的体内功效。
DOI：
10.1002/jbm.b.34528
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Zhang,Yu
中科院分区：
文献类型：
--
作者：
Srinivasan,Kritika;Mijares,DindoQ;Janal,MalvinN;Aranya,AnupamaK;Zhang,DenzilS;LeGeros,RacquelZ;Zhang,Yu
Osteopenia and osteoporosis affect over 40 million US adults 50 years and older. Both diseases are strongly influenced by estrogen and nutritional–mineral deficiencies. This study investigates the efficacy of orally delivered synthetic‐bone‐mineral (SBM), a newly developed calcium phosphate based biomaterial, on reversing bone loss induced by these two critical deficiencies. Thirty 3‐month‐old female rats were randomly allocated to either control—sham surgery on normal diet; or one of the four experimental groups: Sham surgery on a low mineral diet (LMD), ovariectomized (OVX) on LMD, OVX on LMD with SBM with/without fluoride (F). The rats were sacrificed after 6 months, at 9‐month‐old. After 6 months, although all groups lost bone mineral density relative to controls, the supplemented OVX rats showed higher bone mineral density than their unsupplemented counterparts. The 2 SBM supplemented groups improved bone loading capacity by 28.1 and 35.4% compared to the OVX LMD group. Bones from supplemented rats exhibited higher inorganic/organic ratios. The addition of F did not have a significant influence on bone loss. Our findings suggest that SBM supplement is effective in maintaining bone health and offsetting the deleterious effects of estrogen and/or mineral deficiencies on bone density, microarchitecture, and strength.
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影响因子：
3.8
作者：
Otsuka, Makoto;Oshinbe, Ayako;Higuchi, William I.
通讯作者：
Higuchi, William I.
影响因子：
2.8
作者：
Sunyecz JA
通讯作者：
Sunyecz JA
影响因子：
4.1
作者：
SHEN, V;BIRCHMAN, R;DEMPSTER, DW
通讯作者：
DEMPSTER, DW
钙在骨质疏松症药物治疗中的作用。
DOI：
10.1089/jwh.2005.14.180
发表时间：
2005
期刊：
Journal of women's health
影响因子：
--
作者：
J. Sunyecz;S. Weisman
通讯作者：
S. Weisman
DOI：
10.1002/jbm.b.31277
发表时间：
2009-07
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
--
作者：
Y. Tokudome;M. Otsuka;A. Ito;R. Legeros
通讯作者：
Y. Tokudome;M. Otsuka;A. Ito;R. Legeros