Annual Research Review: Perspectives on progress in ADHD science - from characterization to cause.
Annual Research Review: Perspectives on progress in ADHD science - from characterization to cause.
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DOI：
10.1111/jcpp.13696
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发表时间：
2023-04
影响因子：
7.6
通讯作者：
Simonoff, Emily
中科院分区：
文献类型：
--
作者：
Sonuga-Barke, Edmund J. S.;Becker, Stephen P.;Bolte, Sven;Castellanos, Francisco Xavier;Franke, Barbara;Newcorn, Jeffrey H.;Nigg, Joel T.;Rohde, Luis Augusto;Simonoff, Emily
注意力缺陷/多动障碍（ADHD）的科学是由一个转化目标驱动的——发现和利用关于ADHD本质的知识来造福那些受其影响的个体。在过去的五十年里，科学研究在描述多动症的特征和理解其相关性和原因方面取得了巨大的进步。然而，将这些科学见解转化为临床益处是有限的。在这篇综述中，我们对ADHD的科学领域进行了选择性和重点调查，就科学共识的构成、需要强调的重要新线索以及未来需要解决的关键突出问题提供了我们的个人观点。我们涵盖两个广泛的领域-临床特征和，风险因素，因果过程和神经生物学途径。第一部分着重于ADHD的发展过程，共同发生的特征和条件，以及ADHD对生活的功能影响-包括损害，生活质量和耻辱。在第二部分，我们探讨遗传和环境的影响和假定的调解脑过程。在最后一部分，我们根据交叉科学主题和最近将ADHD特征作为更广泛的神经分化的一部分的概念重新表述，反思ADHD结构的未来。
The science of attention-deficit/hyperactivity disorder (ADHD) is motivated by a translational goal – the discovery and exploitation of knowledge about the nature of ADHD to the benefit of those individuals whose lives it affects. Over the past fifty years scientific research has made enormous strides in characterising the ADHD condition and in understanding its correlates and causes. However, the translation of these scientific insights into clinical benefits has been limited. In this review, we provide a selective and focused survey of the scientific field of ADHD, providing our personal perspectives on what constitutes the scientific consensus, important new leads to be highlighted, and the key outstanding questions to be addressed going forward. We cover two broad domains – clinical characterisation and, risk factors, causal processes, and neuro-biological pathways. Part one focuses on the developmental course of ADHD, co-occurring characteristics and conditions, and the functional impact of living with ADHD – including impairment, quality of life, and stigma. In part two, we explore genetic and environmental influences and putative mediating brain processes. In the final section, we reflect on the future of the ADHD construct in the light of cross-cutting scientific themes and recent conceptual reformulations that cast ADHD traits as part of a broader spectrum of neurodivergence.
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影响因子：
6.8
作者：
Cabana-Domínguez J;Torrico B;Reif A;Fernàndez-Castillo N;Cormand B
通讯作者：
Cormand B
DOI：
10.1016/j.jaac.2020.10.016
发表时间：
2021-06
影响因子：
13.3
作者：
Becker SP
通讯作者：
Becker SP
影响因子：
4.7
作者：
Mendonca F;Sudo FK;Santiago-Bravo G;Oliveira N;Assuncao N;Rodrigues F;Soares R;Calil V;Bernardes G;Erthal P;Drummond C;Tovar-Moll F;Mattos P
通讯作者：
Mattos P
影响因子：
6.4
作者：
Bolte, Sven;Mahdi, Soheil;Selb, Melissa
通讯作者：
Selb, Melissa
影响因子：
7.6
作者：
Becker, Stephen P.;Tamm, Leanne;Beebe, Dean W.
通讯作者：
Beebe, Dean W.