Mild Cognitive Impairment or Attention-Deficit/Hyperactivity Disorder in Older Adults? A Cross Sectional Study.
Mild Cognitive Impairment or Attention-Deficit/Hyperactivity Disorder in Older Adults? A Cross Sectional Study.
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DOI：
10.3389/fpsyt.2021.737357
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发表时间：
2021
影响因子：
4.7
通讯作者：
Mattos P
中科院分区：
文献类型：
--
作者：
Mendonca F;Sudo FK;Santiago-Bravo G;Oliveira N;Assuncao N;Rodrigues F;Soares R;Calil V;Bernardes G;Erthal P;Drummond C;Tovar-Moll F;Mattos P
背景：注意缺陷/多动障碍（ADHD）是一种高度普遍的神经发育疾病，可能与终身认知功能障碍有关。据推测，与年龄相关的认知能力下降可能与老年多动症患者先前存在的缺陷重叠，导致管理日常生活活动的问题增加。这种现象可能模仿神经退行性疾病，特别是轻度认知障碍（MCI）。本横断面研究旨在评估老年ADHD患者和轻度认知障碍患者之间的认知和行为差异。方法：共有107名老年参与者（41名对照，40名轻度认知障碍患者，26名多动症患者，平均年龄= 67.60±7.50岁，平均受教育年龄= 15.14±2.77岁，65.4%为女性）在巴西里约热内卢D'Or研究与教育研究所记忆诊所接受了多学科团队的临床、认知和行为评估。各组间比较神经心理任务和行为量表的平均得分。结果：ADHD参与者在情景记忆和执行功能方面的表现比对照组差，具有较大的效应量。轻度认知障碍和多动症在所有领域的表现都具有可比性。讨论：老年个体的轻度认知障碍和注意力缺陷多动症是分离的临床实体，具有重叠的认知特征。临床医生应该意识到这些趋同的表型，以避免误诊。
Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly prevalent neurodevelopmental condition, which may be associated with life-enduring cognitive dysfunction. It has been hypothesized that age-related cognitive decline may overlap with preexisting deficits in older ADHD patients, leading to increased problems to manage everyday-life activities. This phenomenon may mimic neurodegenerative disorders, in particular Mild Cognitive Impairment (MCI). This cross-sectional study aims to assess cognitive and behavioral differences between older subjects with ADHD and MCI. Methods: A total of 107 older participants (41 controls; 40 MCI and 26 ADHD; mean age = 67.60 ± 7.50 years; mean schooling = 15.14 ± 2.77 years; 65.4% females) underwent clinical, cognitive, and behavioral assessments by a multidisciplinary team at the Memory Clinic, D'Or Institute for Research and Education, Rio de Janeiro, Brazil. Mean scores in neuropsychological tasks and behavioral scales were compared across groups. Results: Participants with ADHD showed poorer performances than controls in episodic memory and executive function with large effect-sizes. Performances were comparable between MCI and ADHD for all domains. Discussion: MCI and ADHD in older individuals are dissociated clinical entities with overlapping cognitive profiles. Clinicians ought to be aware of these converging phenotypes to avoid misdiagnosis.
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DOI：
10.1007/s12402-014-0126-1
发表时间：
2014-06
期刊：
Attention deficit and hyperactivity disorders
影响因子：
--
作者：
Fredriksen, Mats;Dahl, Alv A;Martinsen, Egil W;Klungsoyr, Ole;Faraone, Stephen V;Peleikis, Dawn E
通讯作者：
Peleikis, Dawn E
儿童期的注意力缺陷/多动症障碍与老年人群的认知测试概况有关，但与轻度认知障碍或阿尔茨海默氏病无关。
影响因子：
4.7
作者：
Ivanchak N;Abner EL;Carr SA;Freeman SJ;Seybert A;Ranseen J;Jicha GA
通讯作者：
Jicha GA
影响因子：
3.9
作者：
Martyr, Anthony;Clare, Linda;Morris, Robin G.
通讯作者：
Morris, Robin G.
影响因子：
3
作者：
Joseph, Nidhin;Zhang-James, Yanli;Faraone, Stephen V.
通讯作者：
Faraone, Stephen V.
影响因子：
4.8
作者：
Callahan, Brandy L.;Bierstone, Daniel;Black, Sandra E.
通讯作者：
Black, Sandra E.