Poor oral health conditions and cognitive decline: Studies in humans and rats
Poor oral health conditions and cognitive decline: Studies in humans and rats
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口腔健康状况不佳和认知能力下降：对人类和大鼠的研究
DOI：
10.1371/journal.pone.0234659
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发表时间：
2020-07
期刊：
影响因子：
3.7
通讯作者：
Fuhua Yan
中科院分区：
文献类型：
--
作者：
Shuang Zhang;Fengchun Yang;Zezheng Wang;Xueshen Qian;Yan Ji;Ling Gong;Song Ge;Fuhua Yan
背景 口腔健康状况不佳与认知能力下降之间的关系尚不清楚。目的 研究人类和大鼠口腔健康与认知之间的关系。方法在人类中：进行了一项横断面研究。通过简易精神状态检查（MMSE）评估认知水平；口腔状况通过食牙缺失数量、探诊出血和探诊袋深度（PD）来反映。大鼠：建立结扎（Lig）诱导的牙周炎模型和Aβ25-35诱导的阿尔茨海默病（AD）模型；检测海马和大脑皮层肿瘤坏死因子-α（TNF-α）、白介素1（IL-1）、白细胞介素6（IL-6）、C反应蛋白水平。结果 缺失指数牙数≥7组的MMSE评分显着低于≤6组。 MMSE 评分与缺失指数齿的数量之间观察到负相关（相关系数 ρ = -0.310，P = 0.002）。食牙缺失较多和教育水平较低是认知能力下降的独立危险因素。 MMSE 评分与平均 PD 之间存在负相关关系（相关系数 ρ = -0.214，P = 0.031）。 Lig+AD组海马TNF-α、IL-6水平显着高于AD组。 Lig+AD组大脑皮质中IL-1和IL-6的含量显着高于AD组。结论 不良的口腔健康状况，包括更多的食牙缺失和较高的平均 PD 可能是认知能力下降的危险因素。牙周炎可能会增加 AD 大鼠模型中的炎症细胞因子。
Background The relationship between poor oral health conditions and cognitive decline is unclear. Objective To examine the association between oral health and cognition in humans and rats. Methods In humans: a cross-sectional study was conducted. Cognitive levels were evaluated by the Mini Mental State Examination (MMSE); oral conditions were reflected by the number of missing index teeth, bleeding on probing, and probing pocket depth (PD). In rats: a ligature-induced (Lig) periodontitis model and Aβ25-35-induced model of Alzheimer’s disease (AD) were established; tumor necrosis factor-α (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), and C-reactive protein levels in the hippocampus and cerebral cortex were detected. Results MMSE scores for the number of missing index teeth ≥ 7 group were significantly lower than those in the ≤ 6 group. A negative relationship (correlation coefficient ρ = −0.310, P = 0.002) was observed between MMSE scores and number of missing index teeth. More missing index teeth and lower education levels were independent risk factors for cognitive decline. A negative relationship (correlation coefficient ρ = −0.214, P = 0.031) was observed between MMSE scores and average PD. TNF-α and IL-6 levels in the hippocampus of the Lig+AD group were significantly higher than those of the AD group. IL-1 and IL-6 levels in the cerebral cortex of the Lig+AD group were significantly higher than those of the AD group. Conclusion Poor oral health conditions including more missing index teeth and higher average PD may be risk factors for cognitive decline. Periodontitis may increase inflammatory cytokines in rat models of AD.
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影响因子：
7.2
作者：
Selkoe, Dennis J.
通讯作者：
Selkoe, Dennis J.
影响因子：
168.9
作者：
Ballard, Clive;Gauthier, Serge;Jones, Emma
通讯作者：
Jones, Emma
影响因子：
3.7
作者：
Suzuki J;Imai Y;Aoki M;Fujita D;Aoyama N;Tada Y;Wakayama K;Akazawa H;Izumi Y;Isobe M;Komuro I;Nagai R;Hirata Y
通讯作者：
Hirata Y
DOI：
10.1016/j.jalz.2011.04.006
发表时间：
2012-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Sparks Stein P;Steffen MJ;Smith C;Jicha G;Ebersole JL;Abner E;Dawson D 3rd
通讯作者：
Dawson D 3rd
影响因子：
4.8
作者：
Moretti DV;Frisoni GB;Binetti G;Zanetti O
通讯作者：
Zanetti O