Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease.
Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease.
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DOI：
10.1016/j.jalz.2011.04.006
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Dawson D 3rd
中科院分区：
文献类型：
--
作者：
Sparks Stein P;Steffen MJ;Smith C;Jicha G;Ebersole JL;Abner E;Dawson D 3rd
牙周病的慢性炎症被认为是阿尔茨海默病的一个潜在危险因素。本研究的目的是检测最终转变为阿尔茨海默病(AD)的参与者的牙周病细菌抗体水平，并与对照组的抗体水平进行比较。对来自肯塔基大学大脑(神经学研究中的生物韧性成人)研究项目的158名参与者的血清进行了对7种与牙周炎有关的口腔细菌的IgG抗体水平的分析，这些细菌包括：伴生放线菌Aggregati-bacter放线菌、牙龈卟啉单胞菌、直肠弯曲菌、齿轮虫、核梭杆菌、连翘和中间普雷沃特氏菌。所有158名参与者在基线静脉抽血时认知完好无损。其中81名参与者患上了轻度认知障碍(MCI)或阿尔茨海默病(AD)，或者两者都有，而77名对照组在多年的随访中认知完好无损。用Wilcoxon秩和检验比较对照组和AD受试者在基线抽签和转换后的抗体水平，对照组和MCI受试者在基线抽签和转换后的抗体水平。AD和MCI参与者没有被直接比较。线性回归模型被用来调整潜在的混杂。与对照组相比，AD患者在基线血清提取时对核假单胞菌和中间假单胞菌抗体水平显著升高(α=0.0 5)。在控制基线年龄、简易精神状态检查评分和载脂蛋白ε4(载脂蛋白4)状态后，这些结果仍然显著。这项研究提供的初步数据表明，在认知障碍发生前几年，受试者对牙周病细菌的抗体升高，并表明牙周病可能导致AD的发病/进展风险。有必要进行额外的队列研究，描述口腔临床表现与全身反应和AD的关系，以及评估任何因果关系的前瞻性研究。
Chronic inflammation in periodontal disease has been suggested as a potential risk factor in Alzheimer’s disease. The purpose of this study was to examine serum antibody levels to bacteria of periodontal disease in participants who eventually converted to Alzheimer’s disease (AD) compared to the antibody levels in control subjects. Serum from 158 participants in the BRAINS (Biologically Resilient Adults in Neurological Studies) research program at the University of Kentucky were analyzed for IgG antibody levels to 7 oral bacteria associated with periodontitis including: Aggregati-bacter actinomycetemcomitans, Porphyromonas gingivalis, Campylobacter rectus, Tre-ponema denticola, Fusobacterium nucleatum, Tannerella forsythia, and Prevotella intermedia. All 158 participants were cognitively intact at baseline venous blood draw. Eighty one of the participants developed either mild-cognitive impairment (MCI) or Alz-heimer’s disease (AD) or both, and 77 controls remained cognitively intact in the years of follow up. Antibody levels were compared between controls and AD subjects at baseline draw and after conversion and controls and MCI subjects at baseline draw and after conversion using the Wilcoxon rank-sum test. AD and MCI participants were not directly compared. Linear regression models were used to adjust for potential confounding. Antibody levels to F. nucleatum and P. intermedia, were significantly increased (α = 0.05) at baseline serum draw in the AD patients compared to controls. These results remained significant when controlling for baseline age, Mini-Mental State Exam (MMSE) score and apolipoprotein epsilon 4 (APOE ε4) status. This study provides initial data that demonstrate elevated antibodies to periodontal disease bacteria in subjects years prior cognitive impairment and suggests that periodontal disease could potentially contribute to the risk of AD onset/progression. Additional cohort studies profiling oral clinical presentation with systemic response and AD and prospective studies to evaluate any cause-and-effect association are warranted.
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影响因子：
14
作者：
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通讯作者：
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