Interactions between neuroticism and stressful life events predict response to pharmacotherapy for major depression: A CAN-BIND 1 report.
Interactions between neuroticism and stressful life events predict response to pharmacotherapy for major depression: A CAN-BIND 1 report.
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DOI：
10.1002/pmh.1514
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发表时间：
2021-11
影响因子：
2.7
通讯作者：
Quilty LC
中科院分区：
文献类型：
--
作者：
Allen TA;Harkness KL;Lam RW;Milev R;Frey BN;Mueller DJ;Uher R;Kennedy SH;Quilty LC
暴露于压力性生活事件和人格特质神经质的个体差异是相互作用的预测重性抑郁障碍（MDD）的重要危险因素。关于它们对抑郁症治疗反应的影响知之甚少。在这里，我们研究是否有压力的生活事件经历之前和治疗期间与神经质相互作用，以预测对16周的药物治疗MDD的反应。参与者包括159名最初接受8周艾司西酞普兰治疗的MDD门诊患者。对初始治疗有反应的患者继续接受艾司西酞普兰单药治疗，而无反应者接受8周的阿立哌唑连续治疗。使用NEO五因素量表评估人格，使用生活事件和困难量表评估压力生活事件，这是一种严格的情境访谈，包括对威胁性生活事件的独立评级。当患者在治疗前经历了一个或多个负面生活事件时，高基线神经质与较低的反应可能性相关。二次分析表明，这种影响是特定的神经质，并没有更好地解释其自我批评或负面影响方面。我们的研究结果表明，在基线评估人格和压力生活事件可以帮助临床医生评估哪些患者会对抗抑郁治疗产生反应，哪些患者可能需要治疗增强。
Exposure to stressful life events and individual differences in the personality trait neuroticism are important risk factors that interact to predict major depressive disorder (MDD). Less is known about their effect on treatment response in depression. Here, we examine whether stressful life events experienced prior to and during treatment interact with neuroticism to predict response to 16-week pharmacotherapy for MDD. Participants included 159 outpatients with MDD who were initially treated with 8 weeks of escitalopram. Those who responded to the initial treatment continued on escitalopram monotherapy, while non-responders received 8 weeks of adjunctive aripiprazole. Personality was assessed using the NEO-Five Factor Inventory, and stressful life events were assessed using the Life Events and Difficulties Schedule, a rigorous contextual interview that includes independent ratings of threatening life events. High baseline neuroticism was associated with a lower likelihood of response when patients experienced one or more negative life events before treatment. Secondary analyses indicated that this effect was specific to neuroticism, and not better accounted for by its self-criticism or negative affect facets. Our results suggest that assessing personality and stressful life events at baseline can help clinicians assess which patients will respond to antidepressant therapy, and which may need treatment augmentation.
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DOI：
10.1080/10705511.2017.1402334
发表时间：
2018
期刊：
Structural equation modeling : a multidisciplinary journal
影响因子：
--
作者：
Hallquist MN;Wiley JF
通讯作者：
Wiley JF
影响因子：
3.1
作者：
Hatch, Stephani L.;Dohrenwend, Bruce P.
通讯作者：
Dohrenwend, Bruce P.
影响因子：
4.4
作者：
Lam, Raymond W.;Milev, Roumen;Kennedy, Sidney H.
通讯作者：
Kennedy, Sidney H.
影响因子：
5.9
作者：
MONROE, SM;KUPFER, DJ;FRANK, E
通讯作者：
FRANK, E
影响因子：
5.9
作者：
Bulmash, Eric;Harkness, Kate L.;Bagby, R. Michael
通讯作者：
Bagby, R. Michael