Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome.

Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome.
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DOI:
10.1016/j.nutres.2010.06.016
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发表时间:
2010-07
期刊:
Nutrition research (New York, N.Y.)
影响因子:
--
通讯作者:
Lyons TJ
Lyons TJ
中科院分区:
其他
文献类型:
--
作者:
Basu A;Fu DX;Wilkinson M;Simmons B;Wu M;Betts NM;Du M;Lyons TJ

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据报道,在有限的研究中,草莓是有效的抗氧化剂,可以减少心血管危险因素,例如血压升高、高血糖、血脂异常和炎症。我们假设补充冻干草莓可以改善患有代谢综合征的肥胖受试者的血压、血糖受损、血脂异常或循环粘附分子,从而降低这些受试者的心血管危险因素。 27 名患有代谢综合征的受试者 [2 名男性和 25 名女性;体重指数:37.5±2.15公斤/平方米;年龄:47.0±3.0y(平均值±SE)]在一项随机对照试验中,每天饮用 4 杯冻干草莓饮料(50 克冻干草莓 ~ 3 杯新鲜草莓)或等量的液体(对照组,4 杯水),持续八周。在筛选和八周的研究中进行了人体测量和血压测量、饮食摄入量评估和空腹抽血。八周时,使用核磁共振确定的脂蛋白亚类谱 (NMR-LSP) 与对照组相比,补充草莓可显着降低总胆固醇和 LDL 胆固醇 [分别为 5.8±0.2 至 5.2±0.2 mmol/L,以及 3.5±0.2 至 3.1±0.1 mmol/L(平均值±SE),p<0.05] 和小 LDL 颗粒[794.6±94.0 至 681.8±86.0 nmol/L,(平均值±SE),p<0.05]。与对照组相比,第八周时,补充草莓进一步降低了血管细胞粘附分子-1 (VCAM-1) 的循环水平 [272.7±17.4 至 223.0±14.0 ng/mL,(平均值±SE),p<0.05)。血清葡萄糖、甘油三酯、高密度脂蛋白胆固醇、血压和腰围未受影响。因此,短期冻干草莓补充剂改善了代谢综合征受试者中选定的动脉粥样硬化危险因素,包括血脂异常和循环粘附分子,这些结果需要在未来的试验中得到证实。
Strawberries have been reported to be potent antioxidants and reduce cardiovascular risk factors, such as, elevated blood pressure, hyperglycemia, dyslipidemia and inflammation in limited studies. We hypothesized that freeze-dried strawberry supplementation will improve blood pressure, impaired glucose, dyslipidemia, or circulating adhesion molecules in obese subjects with metabolic syndrome, thereby lowering cardiovascular risk factors in these subjects. Twenty-seven subjects with metabolic syndrome [2 males and 25 females; BMI: 37.5±2.15 kg/m2; age: 47.0±3.0y (means ±SE)] consumed 4 cups freeze-dried strawberry beverage (50g freeze-dried strawberries ~ 3 cups fresh strawberries) or equivalent amounts of fluids (controls, 4 cups water) daily for eight weeks in a randomized controlled trial. Anthropometrics and blood pressure measurements, assessment of dietary intakes and fasting blood draws were conducted at screen and eight weeks of the study. Strawberry supplementation significantly decreased total and LDL-cholesterol [5.8±0.2 to 5.2±0.2 mmol/L, and 3.5±0.2 to 3.1±0.1 mmol/L, respectively, (means ±SE), p<0.05] and small LDL-particles using nuclear magnetic resonance-determined lipoprotein subclass profile (NMR-LSP) versus controls at eight weeks [794.6±94.0 to 681.8±86.0 nmol/L, (means ±SE), p<0.05]. Strawberry supplementation further decreased circulating levels of vascular cell adhesion molecule-1 (VCAM-1) versus controls at eight weeks [272.7±17.4 to 223.0±14.0 ng/mL, (means ±SE), p<0.05). Serum glucose, triglycerides, HDL-cholesterol, blood pressure, and waist circumference were not affected. Thus, short-term freeze-dried strawberry supplementation improved selected atherosclerotic risk factors, including, dyslipidemia and circulating adhesion molecules in subjects with metabolic syndrome and these results need confirmation in future trials.
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