Behavioral and neuroanatomical abnormalities in pleiotrophin knockout mice.
Behavioral and neuroanatomical abnormalities in pleiotrophin knockout mice.
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DOI：
10.1371/journal.pone.0100597
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Croll SD
中科院分区：
文献类型：
--
作者：
Krellman JW;Ruiz HH;Marciano VA;Mondrow B;Croll SD
多效营养因子（PTN）是一种细胞外基质相关蛋白，具有神经营养和神经保护作用，参与多种神经发育过程。关于多效营养因子敲除（KO）小鼠的认知行为和神经解剖表型的数据是有限的。本研究的目的是更全面地描述这种表型，重点是学习和记忆，认知行为灵活性，探索行为和焦虑，社会行为，以及外侧内嗅皮层（EC）的神经元和血管显微结构。PTN科斯在新的背景和新的社交互动中表现出认知僵化、焦虑加剧、行为沉默，暗示了新恐惧症，以及外侧EC神经元面积的板层特异性减少和神经元密度的增加。在科斯中，空间和其他联想任务的初始学习以及外侧EC中的血管密度是正常的。这些数据表明，PTN在体内的情况下与特定的认知和情感过程的中断，提高PTN科斯的进一步研究可能有影响的人类疾病的研究具有相似的功能。
Pleiotrophin (PTN) is an extracellular matrix-associated protein with neurotrophic and neuroprotective effects that is involved in a variety of neurodevelopmental processes. Data regarding the cognitive-behavioral and neuroanatomical phenotype of pleiotrophin knockout (KO) mice is limited. The purpose of this study was to more fully characterize this phenotype, with emphasis on the domains of learning and memory, cognitive-behavioral flexibility, exploratory behavior and anxiety, social behavior, and the neuronal and vascular microstructure of the lateral entorhinal cortex (EC). PTN KOs exhibited cognitive rigidity, heightened anxiety, behavioral reticence in novel contexts and novel social interactions suggestive of neophobia, and lamina-specific decreases in neuronal area and increases in neuronal density in the lateral EC. Initial learning of spatial and other associative tasks, as well as vascular density in the lateral EC, was normal in the KOs. These data suggest that the absence of PTN in vivo is associated with disruption of specific cognitive and affective processes, raising the possibility that further study of PTN KOs might have implications for the study of human disorders with similar features.
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影响因子：
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作者：
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影响因子：
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