Rapid Fabrication by Digital Light Processing 3D Printing of a SlipChip with Movable Ports for Local Delivery to Ex Vivo Organ Cultures.
Rapid Fabrication by Digital Light Processing 3D Printing of a SlipChip with Movable Ports for Local Delivery to Ex Vivo Organ Cultures.
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通过数字光处理3D打印快速制造具有可移动端口的滑动芯片，用于局部递送到离体器官培养物。
DOI：
10.3390/mi12080993
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发表时间：
2021-08-20
期刊：
影响因子：
3.4
通讯作者：
Pompano RR
中科院分区：
文献类型：
--
作者：
Catterton MA;Ball AG;Pompano RR
滑板是两部分的微流体设备，可以重新配置以更换整个功能，包括组织刺激，我们测试了数字光处理（DLP）的3D打印是快速，可重复的，并且很容易共享，作为在原型阶段制造的解决方案设计是经过优化，我们通过将化学探针向水凝胶切片和具有多达120 µM空间分辨率的活组织提供了证明。
SlipChips are two-part microfluidic devices that can be reconfigured to change fluidic pathways for a wide range of functions, including tissue stimulation. Currently, fabrication of these devices at the prototype stage requires a skilled microfluidic technician, e.g., for wet etching or alignment steps. In most cases, SlipChip functionality requires an optically clear, smooth, and flat surface that is fluorophilic and hydrophobic. Here, we tested digital light processing (DLP) 3D printing, which is rapid, reproducible, and easily shared, as a solution for fabrication of SlipChips at the prototype stage. As a case study, we sought to fabricate a SlipChip intended for local delivery to live tissue slices through a movable microfluidic port. The device was comprised of two multi-layer components: an enclosed channel with a delivery port and a culture chamber for tissue slices with a permeable support. Once the design was optimized, we demonstrated its function by locally delivering a chemical probe to slices of hydrogel and to living tissue with up to 120 µm spatial resolution. By establishing the design principles for 3D printing of SlipChip devices, this work will enhance the ability to rapidly prototype such devices at mid-scale levels of production.
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影响因子：
4.3
作者：
Beauchamp MJ;Nordin GP;Woolley AT
通讯作者：
Woolley AT
影响因子：
15
作者：
Li, Liang;Du, Wenbin;Ismagilov, Rustem F.
通讯作者：
Ismagilov, Rustem F.
DOI：
10.1021/la204399m
发表时间：
2012-01-24
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Pompano RR;Platt CE;Karymov MA;Ismagilov RF
通讯作者：
Ismagilov RF
影响因子：
6.1
作者：
Catterton, Megan A.;Dunn, Austin F.;Pompano, Rebecca R.
通讯作者：
Pompano, Rebecca R.
DOI：
10.1021/acs.langmuir.1c00625
发表时间：
2021-06-22
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Catterton MA;Montalbine AN;Pompano RR
通讯作者：
Pompano RR