Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice.
Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice.
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DOI：
10.1038/ncomms2718
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发表时间：
2013
影响因子：
16.6
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中科院分区：
文献类型：
--
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肠浆细胞主要产生免疫球蛋白（IG）A，然而，它们的功能多样性仍然很差。在这里，我们表明，小鼠肠道伊加浆细胞可以被新分类为两个群体的基础上的CD 11 B的表达，这不能区分目前已知的标准，如一般的浆细胞标志物，B细胞来源和T细胞依赖性。CD 11b+伊加+浆细胞需要派尔集合淋巴结的淋巴结构，产生比CD 11b −伊加+浆细胞更多的伊加，增殖旺盛，需要微生物刺激和IL-10来发育和维持。这些特征允许CD 11b+伊加+浆细胞介导由蛋白抗原口服免疫诱导的早期抗原特异性肠道伊加应答。这些发现揭示了小鼠肠道中伊加+浆细胞的功能多样性。 肠道浆细胞有助于抵抗病原体的免疫力和肠道菌群耐受性之间的微妙平衡。Kunisawa等人鉴定了浆细胞的亚群，其增殖依赖于微生物和IL-10的刺激，并且介导对口服抗原的早期应答。
Intestinal plasma cells predominantly produce immunoglobulin (Ig) A, however, their functional diversity remains poorly characterized. Here we show that murine intestinal IgA plasma cells can be newly classified into two populations on the basis of CD11b expression, which cannot be discriminated by currently known criteria such as general plasma cell markers, B cell origin and T cell dependence. CD11b+ IgA+ plasma cells require the lymphoid structure of Peyer’s patches, produce more IgA than CD11b− IgA+ plasma cells, proliferate vigorously, and require microbial stimulation and IL-10 for their development and maintenance. These features allow CD11b+ IgA+ plasma cells to mediate early-phase antigen-specific intestinal IgA responses induced by oral immunization with protein antigen. These findings reveal the functional diversity of IgA+ plasma cells in the murine intestine. Intestinal plasma cells contribute to the delicate balance between immunity against pathogens and tolerance of intestinal microflora. Kunisawa et al. identify a subpopulation of plasma cells whose proliferation depends on stimulation by microbes and IL-10, and which mediate early-phase responses to oral antigens.
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影响因子：
8
作者：
Cebra JJ;Jiang HQ;Boiko N;Tlaskalova-Hogenova H
通讯作者：
Tlaskalova-Hogenova H
影响因子：
32.4
作者：
Hou B;Saudan P;Ott G;Wheeler ML;Ji M;Kuzmich L;Lee LM;Coffman RL;Bachmann MF;DeFranco AL
通讯作者：
DeFranco AL
影响因子：
29.7
作者：
Cerutti A;Chen K;Chorny A
通讯作者：
Chorny A
影响因子：
2.5
作者：
Macpherson, Andrew J.;Slack, Emma
通讯作者：
Slack, Emma
影响因子：
4.4
作者：
Hiroi, T;Yanagita, M;Kiyono, H
通讯作者：
Kiyono, H