Influence of maternal dysmetabolic conditions during pregnancy on cardiovascular disease.
Influence of maternal dysmetabolic conditions during pregnancy on cardiovascular disease.
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DOI：
10.1007/s12265-009-9108-7
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发表时间：
2009-09
影响因子：
3.4
通讯作者：
Napoli, Claudio
中科院分区：
文献类型：
--
作者：
Palinski, Wulf;Nicolaides, Eric;Liguori, Antonio;Napoli, Claudio
怀孕期间与母体高胆固醇血症、肥胖和糖尿病相关的致病因素会影响胎儿发育，并使后代易患心血管疾病。动物模型建立了与人类流行病学调查结果一致的因果关系，并原则上表明，怀孕前或怀孕期间的干预措施可以减少或预防子宫内致病性编程。然而，关于母体代谢不良状况增加后代疾病易感性的机制知之甚少。由于编程对后代的影响可能是潜在的，并且可能需要常规风险因素和遗传基因辅助因素成为临床表现，因此识别这些机制变得更加困难。鉴于孕产妇风险因素的日益普遍，预计在未来几十年将导致心血管疾病的浪潮，以及对人类发育规划的前瞻性研究的长度，有必要比以往更加重视实验模型和转化研究。
Pathogenic factors associated with maternal hypercholesterolemia, obesity, and diabetic conditions during pregnancy influence fetal development and predispose offspring to cardiovascular disease. Animal models have established cause–effect relationships consistent with epidemiological findings in humans and have demonstrated, in principle, that interventions before or during pregnancy can reduce or prevent pathogenic in utero programming. However, little is known about the mechanisms by which maternal dysmetabolic conditions enhance disease susceptibility in offspring. Identification of these mechanisms is rendered more difficult by the fact that programming effects in offspring may be latent and may require conventional risk factors and inherited genetic co-factors to become clinically manifest. Given the increasing prevalence of maternal risk factors, which is expected to lead to a wave of cardiovascular disease in the coming decades, and the length of prospective studies on developmental programming in humans, greater-than-usual emphasis on experimental models and translational studies is necessary.
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影响因子：
120.7
作者：
Hedley, AA;Ogden, CL;Flegal, KM
通讯作者：
Flegal, KM
DOI：
10.1161/01.atv.0000282193.31936.fd
发表时间：
2007-10-01
影响因子：
8.7
作者：
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通讯作者：
DeRuiter, Marco C.
影响因子：
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作者：
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影响因子：
158.5
作者：
Barker, DJP;Osmond, C;Eriksson, JG
通讯作者：
Eriksson, JG
影响因子：
3.8
作者：
Aida, K;Wang, XL;Nathanielsz, PW
通讯作者：
Nathanielsz, PW