A novel anti Candida albicans drug screening system based on high-throughput microfluidic chips
A novel anti Candida albicans drug screening system based on high-throughput microfluidic chips
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基于高通量微流控芯片的新型抗白色念珠菌药物筛选系统
DOI：
10.1038/s41598-019-44298-w
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发表时间：
2019-05
影响因子：
4.6
通讯作者：
韩琳
中科院分区：
文献类型：
--
作者：
韩琳
Due to the antibacterial resistance crisis, developing new antibacterials is of particular interest. In this study, we combined the antifungal drug amphotericin B with 50,520 different small molecule compounds obtained from the Chinese National Compound Library in an attempt to improve its efficacy against Candida albicans persister cells. To systematically study the antifungal effect of each compound, we utilized custom-designed high-throughput microfluidic chips. Our microfluidic chips contained microchannels ranging from 3 µm to 5 µm in width to allow Candida albicans cells to line up one-by-one to facilitate fluorescence-microscope viewing. After screening, we were left with 10 small molecule compounds that improved the antifungal effects of amphotericin B more than 30% against Candida albicans persister cells.
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DOI：
10.1271/bbb1961.47.2889
发表时间：
1983-12
期刊：
Agricultural and biological chemistry
影响因子：
--
作者：
I. Yamashita;S. Fukui
通讯作者：
I. Yamashita;S. Fukui
白色念珠菌在阴道粘膜上形成生物膜。
DOI：
10.1099/mic.0.039354-0
发表时间：
2010-12
期刊：
Microbiology (Reading, England)
影响因子：
--
作者：
Harriott MM;Lilly EA;Rodriguez TE;Fidel PL;Noverr MC
通讯作者：
Noverr MC
影响因子：
6.7
作者：
Rukang Zhang;Jiang Wang;Liang Zhao;Shien Liu;Daohai Du;H. Ding;Shijie Chen;Liyan Yue;Yu-Chih Liu;Chen-hua Zhang;Hong Liu;C. Luo
通讯作者：
Rukang Zhang;Jiang Wang;Liang Zhao;Shien Liu;Daohai Du;H. Ding;Shijie Chen;Liyan Yue;Yu-Chih Liu;Chen-hua Zhang;Hong Liu;C. Luo
影响因子：
2.9
作者：
Xiaoling Tang;H. Suo;R. Zheng;Yuguo Zheng
通讯作者：
Xiaoling Tang;H. Suo;R. Zheng;Yuguo Zheng
影响因子：
5.9
作者：
Krzyściak W;Kościelniak D;Papież M;Vyhouskaya P;Zagórska-Świeży K;Kołodziej I;Bystrowska B;Jurczak A
通讯作者：
Jurczak A