Cytotoxic T lymphocytes specific for influenza virus.
Cytotoxic T lymphocytes specific for influenza virus.
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流感病毒特异性细胞毒性 T 淋巴细胞。
DOI：
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发表时间：
1994
影响因子：
--
通讯作者：
Andrew J. McMichael
中科院分区：
文献类型：
--
作者：
Andrew J. McMichael
Influenza virus has proved an excellent model for the study of the specificity of cytotoxic T lymphocytes (CTL) and of the processing of viral antigens. Fundamental information about these processes has been gained in both mice and humans. At the same time, a considerable amount has been learned about the role of CTL in influenza viral infections, particularly in mice. The virus has proved to be a malleable tool because it can be readily grown, the full nucleotide structure has been determined (in the 1970s; reviewed in Lamb 1983), there are multiple antigenic variants, many of which have been sequenced, the three-dimensional structures of haemagglutinin and neuraminidase are known (Varghese et al. 1983; Wiley et al. 1981) and, for human studies, it has the advantage that it has infected a very high percentage of the population. All of these features combine to make this a safe and invaluable model for the study of theoretical aspects of T cell function as well as investigating the practical issues of how T cells control virus infections. Studies with influenza virus answered long-standing questions about the interaction between viral antigens and class I molecules of the major histocompatibility complex (MHC). Along the way came information about mutant and variant MHC molecules and the demonstration that peptide epitopes presented by class I MHC molecules are recognised by CTL. More recently, the virus has been invaluable for the elucidation of the antigenprocessing pathways.
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可通过细胞毒性 T 淋巴细胞区分的 HLA-A2 抗原的比较结构分析：变体 M7 和 DR1。
影响因子：
2.9
作者：
Krangel,MS;Taketani,S;Biddison,WE;Strong,DM;Strominger,JL
通讯作者：
Strominger,JL
DOI：
10.1073/pnas.82.6.1785
发表时间：
1985-01-01
影响因子：
11.1
作者：
YEWDELL, JW;BENNINK, JR;MOSS, B
通讯作者：
MOSS, B
细胞毒性 T 淋巴细胞识别表达 SV40 肿瘤抗原片段的细胞。
DOI：
--
发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gooding,LR;O'Connell,KA
通讯作者：
O'Connell,KA
影响因子：
56.9
作者：
HUNT, DF;HENDERSON, RA;ENGELHARD, VH
通讯作者：
ENGELHARD, VH
影响因子：
56.9
作者：
PIATAK, M;SAAG, MS;LIFSON, JD
通讯作者：
LIFSON, JD