Effects of human milk on body composition and growth in very low birthweight infants.

Effects of human milk on body composition and growth in very low birthweight infants.
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DOI:
10.1038/s41390-022-02364-6
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发表时间:
2023-06
期刊:
影响因子:
3.6
通讯作者:
Moreira, Alvaro G.
Moreira, Alvaro G.
中科院分区:
医学3区
文献类型:
--
作者:
Ramirez, Carina B.;McCoy, Karli L.;Jacob, Rachel;Lavender, Elizabeth;Bonagurio, Krista;Guerra, Diana Anzueto;Karottakuttu, Simon;Gelfond, Jonathon;McCurnin, Donald;Blanco, Cynthia L.;Moreira, Alvaro G.

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比较不同母乳来源的极低出生体重儿的身体组成和生长情况:母乳(MEBM)与供体母乳(DBM)。我们假设,与那些主要喂食DBM的婴儿相比,主要喂食MEBM的婴儿将表现出体脂百分比降低。2017年至2021年期间,体重≤ 1500 g的早产儿仅接受人乳饮食入组了一项单中心研究。收集了人口统计学数据和人体测量数据。所有婴儿在月经后36周时通过双能x线吸收法进行身体成分分析。60例婴儿入组,48例纳入主要分析。在体脂百分比(14% vs.12%,p=0.7)或无脂质量(2050 g vs.2130 g,p=0.7)方面未检测到差异。两组显示出相似的生长和人体测量。两组的热量和常量营养素摄入量相似。在研究的患者队列中,在出生后前28天内,基于主要母乳类型摄入量,未观察到体脂百分比差异。需要在更大的纯母乳喂养早产儿人群中进行进一步研究,以确定是否存在基于婴儿主要母乳来源的身体组成差异。
To compare body composition and growth in very low birth weight infants according to their source of human milk: maternal expressed breast milk (MEBM) versus donor breast milk (DBM). We hypothesized that infants fed predominately MEBM would exhibit reduced body fat percentage compared to those fed predominately DBM. Premature infants weighing ≤1500g on an exclusive human milk diet were enrolled in a single-center study between 2017 and 2021. Demographic data and anthropometric measurements were collected. All infants underwent body composition analysis via dual energy x-ray absorptiometry at 36 weeks corrected post menstrual age. 60 infants were enrolled and 48 were included in the primary analysis. No differences were detected in percent body fat (14% vs.12%, p=0.7) or fat-free mass (2050g vs. 2130g p=0.7). Both groups displayed similar growth and anthropometric measurements. Caloric and macronutrient intake between groups was similar. In the cohort of patients studied, no differences were observed in percent body fat based on primary human milk type intake in the first 28 postnatal days. Further investigation is required in a larger population of exclusive human milk fed preterm infants to determine if body composition differences exist based on an infant’s primary human milk source.
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