Language reorganization in patients with left-hemispheric gliomas is associated with increased cortical volume in language-related areas and in the default mode network.
Language reorganization in patients with left-hemispheric gliomas is associated with increased cortical volume in language-related areas and in the default mode network.
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DOI：
10.1016/j.cortex.2022.09.014
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发表时间：
2022-12
期刊：
影响因子：
3.6
通讯作者：
Holodny, Andrei I.
中科院分区：
文献类型：
--
作者：
Pasquini, Luca;Jenabi, Mehrnaz;Peck, Kyung K.;Holodny, Andrei I.
语言功能可能会重组，以克服局灶性损害，然而，脑肿瘤患者的功能和结构变化之间的关系仍不清楚。我们研究了非典型语言优势型（AD）患者左额-岛叶高级别（HGG）和低级别胶质瘤（LGG）的皮质体积。我们假设非典型语言与右半球皮质体积增加的区域有关，包括语言区同源物。入选标准：左额-岛叶胶质瘤;功能MRI和3DT 1加权图像;无伪影。我们计算了大脑半球语言偏侧化指数（LI），定义为：如果LI<0.2，则为AD;如果LI>=0.2，则为左优势（LD）。我们在三种基于体素的形态测定（VBM）分析中测量了皮质体积：总AD与LD患者; HGG中AD与LD; LGG中AD与LD。我们在AD与LD健康对照（HC）中重复分析。采用t>2的最小阈值和校正的p<0.025（Bonferroni）。我们招募了119例患者（44例LGG，75例HGG）。119例AD和119例LD患者中分别有64例和55例出现半球LI。第一次VBM分析表明，AD患者的右侧额下回（IFG）、右侧上级颞回（STG）、右侧颞叶、右侧梭状回（FG）、右侧中央前回、右侧颞顶交界区、右侧后扣带回皮质（PCC）、右侧海马、右侧和左侧小脑的皮质体积显著增加。HGG的AD患者显示相同区域的皮质体积显著增加。伴有LGG的AD患者右侧IFG、右侧STG、右侧前扣带回、右侧前扣带回、右侧PCC、右侧背外侧前额叶皮质体积显著增加。HC显示无显著结果。左半球胶质瘤患者的右侧（非典型）语言激活与皮质体积增加相关。此外，无论肿瘤级别如何，默认模式网络节点都显示AD患者的皮质体积更大，这支持了这些皮质参与语言可塑性发展的观点。
Language function may reorganize to overcome focal impairment; however, the relation between functional and structural changes in patients with brain tumors remains unclear. We investigated the cortical volume of atypical language dominant (AD) patients with left frontal-insular high-grade (HGG) and low-grade glioma (LGG). We hypothesized atypical language being associated with areas of increased cortical volume in the right hemisphere, including language areas homologues. Patient were recruited following the criteria: left frontal-insular glioma; functional MRI and 3DT1-weighted images; no artifacts. We calculated an hemispheric language laterality index (LI), defined as: AD if LI<0.2; left-dominant (LD) if LI>=0.2. We measured cortical volume in three voxel-based morphometry (VBM) analyses: total AD vs. LD patients; AD vs. LD in HGG; AD vs. LD in LGG. We repeated the analysis in AD vs. LD healthy controls (HC). A minimum threshold of t>2 and corrected p<0.025 (Bonferroni) was employed. We recruited 119 patients (44LGG, 75HGG). Hemispheric LI demonstrated 64/119AD and 55/119LD patients. The first VBM analysis demonstrated significantly increased cortical volume in AD patients in the right inferior frontal gyrus (IFG), right superior temporal gyrus (STG), right insula, right fusiform gyrus (FG), right precentral gyrus, right temporal-parietal junction, right posterior cingulate cortex (PCC), right hippocampus, right- and left cerebellum. AD patients with HGG showed the same areas of significantly increased cortical volume. AD patients with LGG displayed significantly increased cortical volume in right IFG, right STG, right insula, right FG, right anterior cingulate cortex, right PCC, right dorsal-lateral prefrontal cortex. HC showed no significant results. Right-sided (atypical) language activations in patients with left-hemispheric gliomas are associated with areas of increased cortical volume. Additionally, default mode network nodes showed greater cortical volume in AD patients regardless of the tumor grade, supporting the idea of these cortices participating in the development of language plasticity.
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