Cadaveric Stem Cells: Their Research Potential and Limitations.
Cadaveric Stem Cells: Their Research Potential and Limitations.
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DOI：
10.3389/fgene.2021.798161
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发表时间：
2021
影响因子：
3.7
通讯作者：
Tomsia M
中科院分区：
文献类型：
--
作者：
Cieśla J;Tomsia M
在人们对干细胞的兴趣与日俱增的时代，可供移植的捐赠者已经成为一个问题。胚胎和胎儿细胞的分离引发了伦理争议，成年捐赠者的数量也很少。从已故捐赠者身上分离出的干细胞，即身体干细胞(CASCs)，可能会缓解这一问题。到目前为止，已有可能从已故供者身上分离出间充质干细胞(MSCs)、脂肪源性干细胞(ADSCs)、神经干细胞(NSCs)、视网膜前体细胞(RPC)、诱导多能干细胞(IPSCs)和造血干细胞(HSCs)。最近的研究表明，从身体中收集和使用CASCs是可能的，即使是那些具有延长的死后间隔(PMI)的CASCs，只要保持适当的储存条件(如身体肝素化或液氮储存)。现就CASCs的最新研究及其治疗应用作一综述。描述了身体细胞转录组和支架的研究进展，总结了它们在再生医学中的潜在应用，并列举了它们的局限性，如刑事案件中捐赠者的未知医疗状况、有限的分化潜力、较高的致癌风险或DNA质量变化。最后，审查强调需要制定程序，以确定安全的CASCs收获和使用。
In the era of growing interest in stem cells, the availability of donors for transplantation has become a problem. The isolation of embryonic and fetal cells raises ethical controversies, and the number of adult donors is deficient. Stem cells isolated from deceased donors, known as cadaveric stem cells (CaSCs), may alleviate this problem. So far, it was possible to isolate from deceased donors mesenchymal stem cells (MSCs), adipose delivered stem cells (ADSCs), neural stem cells (NSCs), retinal progenitor cells (RPCs), induced pluripotent stem cells (iPSCs), and hematopoietic stem cells (HSCs). Recent studies have shown that it is possible to collect and use CaSCs from cadavers, even these with an extended postmortem interval (PMI) provided proper storage conditions (like cadaver heparinization or liquid nitrogen storage) are maintained. The presented review summarizes the latest research on CaSCs and their current therapeutic applications. It describes the developments in thanatotranscriptome and scaffolding for cadaver cells, summarizes their potential applications in regenerative medicine, and lists their limitations, such as donor’s unknown medical condition in criminal cases, limited differentiation potential, higher risk of carcinogenesis, or changing DNA quality. Finally, the review underlines the need to develop procedures determining the safe CaSCs harvesting and use.
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影响因子：
8
作者：
Andrzejewska A;Nowakowski A;Janowski M;Bulte JW;Gilad AA;Walczak P;Lukomska B
通讯作者：
Lukomska B
影响因子：
3.7
作者：
Bliss LA;Sams MR;Deep-Soboslay A;Ren-Patterson R;Jaffe AE;Chenoweth JG;Jaishankar A;Kleinman JE;Hyde TM
通讯作者：
Hyde TM
影响因子：
11.2
作者：
Obenaus, Andre;Dilmac, Nejmi;Tone, Beatriz;Tian, Hou Rou;Hartman, Richard;Digicaylioglu, Murat;Snyder, Evan Y.;Ashwal, Stephen
通讯作者：
Ashwal, Stephen
影响因子：
2.6
作者：
Bartholomew, A;Sturgeon, C;Hoffman, R
通讯作者：
Hoffman, R
影响因子：
6.1
作者：
De Pauw, L;Abramowicz, D;Goldman, M
通讯作者：
Goldman, M