Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia.
Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia.
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DOI：
10.3201/eid1611.090934
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发表时间：
2010-11
影响因子：
11.8
通讯作者：
Sack DA
中科院分区：
文献类型：
--
作者：
Bardhan P;Faruque AS;Naheed A;Sack DA
尽管病例数很高，但自20世纪80年代以来死亡人数已下降98%。1999年，对1966-1997年文献的审查表明，每年有110万人死于志贺氏菌病，其中亚洲有188万人。我们最近对1990-2009年文献的回顾表明，亚洲每年发生1.25亿志贺氏菌病病例，其中1.40万例是致命的。这一疾病估计数与先前的估计数相似，但死亡人数减少了98%;也就是说，死亡人数估计数的减少与病死率的显著降低有关，而不是与病例数的减少有关。在没有志贺氏菌特定干预措施的时期内，志贺氏菌相关死亡大幅下降。我们推测，非特异性干预，例如，麻疹疫苗接种、维生素A补充和营养改善可能导致志贺氏菌病相关死亡人数减少。
Despite a high number of cases, deaths have decreased 98% since the 1980s. In 1999, a review of the literature for 1966–1997 suggested that ≈1.1 million persons die annually of shigellosis, including ≈880,000 in Asia. Our recent review of the literature for 1990–2009 indicates that ≈125 million shigellosis cases occur annually in Asia, of which ≈14,000 are fatal. This estimate for illnesses is similar to the earlier estimate, but the number of deaths is 98% lower; that is, the lower estimate of deaths is associated with markedly reduced case-fatality rates rather than fewer cases. Shigella spp.–related deaths decreased substantially during a period without Shigella spp.–specific interventions. We speculate that nonspecific interventions, e.g., measles vaccination, vitamin A supplementation, and improved nutrition, may have led to the reduced number of shigellosis-related deaths.
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影响因子：
6.4
作者：
Ashkenazi, S;Passwell, JH;Schneerson, R
通讯作者：
Schneerson, R
影响因子：
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3.1
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通讯作者：
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