T cell regulation of IgG subclass antibody production in response to T-independent antigens.
T cell regulation of IgG subclass antibody production in response to T-independent antigens.
复制标题
T细胞调节IgG亚类抗体的产生，响应于T独立抗原。
DOI：
10.1084/jem.153.1.1
复制
发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
Paul WE
中科院分区：
文献类型：
--
作者：
Mongini PK;Stein KE;Paul WE
研究了T淋巴细胞对B淋巴细胞对2型T非依赖性抗原三硝基苯基化（TNP）-Ficoll和TNP-Levan的IgM、IgG 3、IgG 1、IgG 2 B和IgG 2a应答的影响。发现携带T细胞的nu/+小鼠比它们的无胸腺对应物产生显著更高的IgG 2血清抗TNP抗体，并且nu/nu和nu/+ IgG 2a滴度比nu/nu和nu/+ IgG 2b滴度表现出更大的差异。nu/nu和nu/+小鼠中的Igm、IgG 3和IgG 1抗TNP水平不可区分。通过细胞转移实验，确定裸和杂合子IgG 2应答的这种差异不能用两种品系之间的B细胞差异或对nu/nu小鼠内IgG 2产生的抑制作用来解释。相反，这种差异被证明是B细胞对抗原应答时T细胞缺失的结果。在不存在T细胞的情况下，发现nu/nu抗TNP抗体应答的强度按以下顺序：IgM > IgG 3> IgG 1> IgG 2b> IgG 2a，这与最近提出的重链基因顺序相同。T细胞通过其特异性识别IgG 2-轴承B细胞或通过信号，以增加重链开关的响应B细胞克隆的影响IgG 2生产的可能性进行了讨论。
The effect of T lymphocytes on the IgM, IgG3, IgG1, IgG2b, and IgG2a responses of B lymphocytes to the type-2 T-independent antigens, trinitrophenylated (TNP)-Ficoll, and TNP-Levan, was investigated. T cell-bearing nu/+ mice were found to produce substantially higher IgG2 serum anti-TNP antibody than their athymic counterparts, and nu/nu and nu/+ IgG2a titers exhibiting more disparity than nu/nu and nu/+ IgG2b titers. The Igm, IgG3, and IgG1 anti-TNP levels in nu/nu and nu/+ mice were indistinguishable. By cell transfer experiments, it was determined that this variance in nude and heterozygote IgG2 responses could not be explained by B cell differences between the two strains or by suppressive effects on IgG2 production within nu/nu mice. Rather, the difference was shown to be the result of the absence of T cells at the time B cells were responding to antigen. In the absence of T cells, the strength of the nu/nu anti-TNP antibody response was found to be in the following order: IgM > IgG3 > IgG1 > IgG2b > IgG2a, a heirarchy identical with the recently proposed heavy chain gene order. The possibilities that T cells influence IgG2 production via their specific recognition of IgG2-bearing B cells or via signals to increase heavy chain switching of responding B cell clones are discussed.
登录
查看更多内容
影响因子：
15.3
作者：
SLACK, J;DERBALIAN, GP;DAVIE, JM
通讯作者：
DAVIE, JM
影响因子：
5.4
作者：
HETZELBERGER, D;EICHMANN, K
通讯作者：
EICHMANN, K
小鼠的免疫球蛋白。 V.五个免疫球蛋白类别的代谢（分解代谢）特性。
影响因子：
15.3
作者：
FAHEY, J L;SELL, S
通讯作者：
SELL, S
DOI：
10.1016/0161-5890(78)90070-6
发表时间：
1978-01-01
期刊：
IMMUNOCHEMISTRY
影响因子：
--
作者：
EY, PL;PROWSE, SJ;JENKIN, CR
通讯作者：
JENKIN, CR
DOI：
10.1073/pnas.75.5.2140
发表时间：
1978-01-01
影响因子：
11.1
作者：
HONJO, T;KATAOKA, T
通讯作者：
KATAOKA, T